Gastroesophageal Reflux, Laryngitis
Conditions
Keywords
Reflux laryngitis
Brief summary
The purpose of this study is to evaluate the efficacy of rabeprazole (pariet) versus placebo in treating reflux laryngitis in Chinese patients. Patients who attend the voice clinic of Department of ENT, Queen Mary hospital with suspected reflux laryngitis will be recruited. A questionnaire will be administered by the research assistant of the Department of Medicine and ENT, Queen Mary hospital. A 12-week course of PPI versus placebo trial will be commenced and patients' symptoms and signs will be documented at 6-week and 12-week time. The study will finish after a 12-week course of rabeprazole.
Interventions
Sponsors
The University of Hong Kong
Hospital Authority, Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* Ambulatory patients with age between 18-80 years old * Patients with newly presented laryngitis.
Exclusion criteria
* They were under 18 or over 80 years of age * Has significant concomitant medical disease * Pregnancy or lactating women * Chronic cough attributable to known chronic pulmonary or tracheobronchial disease * Previous glottal surgery, radiotherapy or malignancy * Acid suppressive therapy within 4 wk prior to recruitment * Pharyngo-laryngeal infection in the previous 3 months * Tracheal intubation in previous 12 months * Immunosuppression and use of inhaled corticosteroid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptoms assessment, quality of life. | 12 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Compliance | 4 weeks |
| Adverse effects | 4 weeks |
Countries
China
Outcome results
None listed