The Innate Immune System and Inflammatory Bowel Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00516776

Enrollment

400

Registered

2007-08-15

Start date

2007-06-30

Completion date

2017-12-31

Last updated

2018-02-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's Disease, Ulcerative Colitis

Brief summary

The study includes individuals with ulcerative colitis, Crohn's disease and healthy controls. The purpose of this study is to examine the innate immune system (IIS) by exposing peripheral blood monocytes to various ligands relevant for stimulation of the IIS and study the immune response. Colonic mucosal samples are examined to find gene expression patterns which may distinguish the two forms of disease from each other and from healthy controls. The hypothesis is that the innate immune system has responses unique for the disease states, and that the diseases may be differentiated by examination of gene expression patterns in mucosal biopsies.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Presence of ulcerative colitis * Presence of Crohn's disease * Healthy (no sign of inflammatory bowel disease)

Exclusion criteria

* Anticoagulation * Cardiac valvular disease * Intravascular prosthesis * Coagulation disorders * Gastrointestinal malignancy

Design outcomes

Primary

Measure	Time frame
gene expression patterns in mucosal biopsies	2 years

Countries

Norway

Outcome results