Role of Volatile Anesthetics for Hepatic Protection

Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00516711

Enrollment

Unknown

Registered

2007-08-15

Start date

2006-03-31

Completion date

2007-12-31

Last updated

2010-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reperfusion Injury

Keywords

Surgery with Pringle maneuver needed for liver resection

Brief summary

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Detailed description

Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Interventions

DRUGSevoflurane

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Older than 18 years of age * Patients undergoing liver resection (benign or malignant tumors)

Exclusion criteria

* Laparoscopic liver resection coagulopathy (platelets \< 50,000/ml, Quick \< 50%) * Liver cirrhosis

Design outcomes

Primary

Measure	Time frame
Blood levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT)	—

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 4, 2026