Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis Colorectal Cancer

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00516230

Enrollment

200

Registered

2007-08-15

Start date

2006-01-31

Completion date

2011-12-31

Last updated

2007-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colonic Neoplasms

Keywords

Colonic Neoplasms, Lynch syndrome

Brief summary

Correct identification of Lynch syndrome at the time of colorectal cancer presentation is important. We aim to find best ways to screen patients with colorectal cancer in Korea.

Detailed description

Patients with newly diagnoised colorectal cancer will be eligible. They will undergo detailed history taking including family history, and molecular stuidies including microsatellite instability test and immunohistochemistry for DNA mismatch repair protein with pre-selection. Any abnormal finding in molecular stuides will be offered genetic testing (after testing methylation status for patients with abnormalities in MLH1).

Interventions

None listed

Study design

Observational model

DEFINED_POPULATION

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Colorectal cancer

Exclusion criteria

* Histology showing other than adenocarcinoma

Countries

South Korea

Contacts

Primary ContactDong Kyung Chang, M.D. Ph.D

dkchang@skku.edu+82-2-3410-3409

Backup ContactTae Kuen Kim

tggo.kim@samsung.com+82-2-3410-2975

Outcome results