One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators

Lung: One-lung Ventilation: Expression of Pulmonary Inflammatory Mediators After Deflation and Re-expansion of the Lung During Thoracic Surgery

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00515905

Enrollment

Registered

2007-08-14

Start date

2004-10-31

Completion date

2007-09-30

Last updated

2010-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thoracic Surgery With One-lung Ventilation

Brief summary

One-lung ventilation; organ protection; volatile anesthetics One-lung ventilation has become a common procedure for thoracoscopic surgery. Two hypothesis will be tested in this study: 1. Are inflammatory mediators increased in the re-ventilated lung after short-period pulmonary collapse? 2. Does Sevoflurane influence the production of inflammatory mediators in the re-inflated lung? Therefore, this study will elucidate the potential protective effect of a volatile anaesthetic (sevoflurane) on the production of inflammatory mediators by the respiratory compartment of the lung, i.e. the alveolar epithelium. * Trial with immunomodulatory product / biological

Interventions

DRUGSevoflurane/propofol

Sevoflurane/propofol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Thoracic surgery (thoracotomy, thoracoscopy) with one-lung ventilation

Exclusion criteria

* Immunosuppressive therapy * Ongoing inflammatory processes

Design outcomes

Primary

Measure	Time frame
One-lung ventilation measurement in the re-ventilated lung after short-period pulmonary collapse	Sep 07

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026