Asthma, Respiratory
Conditions
Brief summary
Breathing retraining supervised by a physiotherapist will result in improvements in the quality of life and asthma control of patients treated for asthma in the community with symptoms suggestive of dysfunctional breathing. To investigate the effects of breathing retraining on clinical and physiological parameters of asthma control, to identify the characteristics of patients who benefit, to perform a health economic evaluation.
Detailed description
Objectives: * To assess the effect of breathing retraining on asthma-related health status, asthma control and objective indices of asthma severity (bronchial hyper-reactivity (BHR), sputum eosinophilia and nitric oxide production) in patients with symptomatic asthma. * To compare the relationship between symptoms of dysfunctional breathing (Nijmegen Questionnaire screening score), changes in asthma-related health status and other parameters resulting from breathing retraining * To explore the relationship between dysfunctional breathing, baseline asthma symptoms, treatment and asthma-related quality of life. * To estimate the cost effectiveness of the breathing retraining intervention
Interventions
OTHERPhysiotherapist
Physiotherapist administered breathing retraining programme
Sponsors
University Hospitals, Leicester
P Burns
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
17 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Asthma diagnosis in medical records * Age 17-70 yrs. * One or more prescription for asthma medication in previous 12 months * Impaired asthma related quality of life (AQLQ score \<5.5)
Exclusion criteria
* COPD * Unstable or under-treated asthma at enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in AQLQ scores between intervention and control groups in subjects with positive NQ screening scores 1 month post intervention Change in AQLQ scores between intervention groups of subjects with positive and negative NQ screening scores | Dec 2006 |
Secondary
| Measure | Time frame |
|---|---|
| Changes in bronchial hyperresponsiveness(PC 20), sputum eosinophil counts and exhaled NO between intervention and control groups in subjects with positive and negative NQ screening scores Change in ACQ Score between the intervention and the control gr | Dec 2007 |
Outcome results
None listed