Antidepressant Effect of Theta-Burst rTMS

Status

UNKNOWN

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00515658

Enrollment

Unknown

Registered

2007-08-14

Start date

2007-03-31

Completion date

Unknown

Last updated

2007-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depression

Keywords

Major depression, Theta-burst rTMS, Cortical excitability, Hamilton depression rating scale

Brief summary

The aim of this study is to evaluate the safety and efficacy of theta-burst rTMS in patients with major depression. Patients will be randomized to receive ether left-sided intermittent theta-burst rTMS or rigt-sided continuous theta-burst rTMS or sham theta-burst rTMS over two weeks period with an option for an additional two weeks period, depending on treatment response. Clinical assessments will be performed weekly by the Hamilton depression rating scale. In addition, standard neurophysiological assessment of cortical excitability will be done.

Interventions

DEVICEtheta-burst rTMS

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Major depressive episode (DSM IV criteria). * Informed consent. * Age: 18-70.

Exclusion criteria

* Suicidality * Psychosis * Pacemaker * Cardiac arrythmia * seizure disorder * implantable metal devices * PNS and CNS disorders * any other contraindications as specified in safety guidelines for rTMS (Wassermenn, 1998).

Countries

Israel

Contacts

Primary ContactEhud Klein, MD

e_klein@rambam.health.gov.il972-4-8543599

Backup ContactAndrei Chistyakov, PhD

a_chistyakov@rambam.health.gov.il972-4-8543695

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026