Noninvasive Positive Pressure Ventilation Using Helium:Oxygen Versus Air:Oxygen in Acute Respiratory Failure in Chronic Obstructive Pulmonary Disease Patients Exposed to Sulfur Mustard

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00515606

Enrollment

Unknown

Registered

2007-08-14

Start date

2007-02-28

Completion date

2007-06-30

Last updated

2007-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchiolitis, Chronic Obstructive Pulmonary Disease

Brief summary

to assess the effectiveness of helium:oxygen mixture adjunct with non-invasive ventilation in sulfur mustard exposed patients with acute decompensation

Interventions

DRUGhelium:oxygen

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

38 Years to 59 Years

Inclusion criteria

* a history of previous exposure to sulfur mustard * worsening dyspnea during the last 10 days * respiratory rate \>25/min * arterial pH\<7.35 * PaCO2 of \>50 mmHg * PaO2 of \<50 mmHg

Exclusion criteria

* recent pneumothorax (\<1 month) * severe respiratory failure or hemodynamic instability with forthcoming intubation * FIO2 of \<0.4 * impaired consciousness or absence of patient cooperation * facial lesions precluding NIV

Design outcomes

Primary

Measure	Time frame
assess spirometry and hemodynamic measures after heliox or air:oxygen use	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026