Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)

Randomized, Clinical Trial to Study the Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function, Oxidative Stress and Regenerative Capacity of Endothelial Progenitor Cells in Patients With Metabolic Syndrome

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00515476

Acronym

HERMET

Enrollment

Registered

2007-08-13

Start date

2007-06-30

Completion date

2008-12-31

Last updated

2010-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic Syndrome X

Keywords

metabolic syndrome, HDL-Cholesterol, EPC, endothelial function, reduced blood HDL-Cholesterol level

Brief summary

The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-Cholesterol in these patients. Additionally the investigators aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with metabolic syndrome and the changes dependent on physical activity of patients.

Interventions

BEHAVIORALphysical exercise

8 weeks of regular exercise training

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

21 Years to 75 Years

Healthy volunteers

Yes

Inclusion criteria

* Reduced HDL-Cholesterol levels in blood: \< 40 mg/dl (1.03 mmol/L) in male, \< 50 mg/dl (1.29 mmol/L) in female * Plus two of the following criteria: * Elevated waist circumference: ≥ 102 cm (≥ 40 inches) in men or ≥ 88 cm (≥ 35 inches) in women * Elevated triglycerides: ≥ 150 mg/dL (1.7 mmol/L * Elevated blood pressure: ≥ 130 mmHg systolic blood pressure or ≥ 80 mmHg * diastolic blood pressure or anti-hypertensive treatment * Elevated fasting glucose: ≥ 100 mg/dL or on drug treatment for elevated fasting glucose

Exclusion criteria

* Acute coronary syndrome * Unstable Angina pectoris * Myocardial infarction during the last 8 weeks * Therapy with Niacin * Active infections * Ventricular arrhythmias * Systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 95 mmHg * Cancer * Pregnancy, lactation * Alcoholism

Design outcomes

Primary

Measure	Time frame
Primary: vasculoprotective and regenerative functions of HDL-Cholesterol and EPC function before and after 8-weeks exercise training	before and after 8-weeks exercise training

Secondary

Measure	Time frame
Secondary: flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound	before and 8 weeks after exercise training

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026