Coronary Artery Disease, Type 2 Diabetes
Conditions
Brief summary
The purpose of this study is to explore the recurrence risk of cardiovascular events in patients with type 2 diabetes mellitus and coronary heart disease after different antidiabetic drug therapy (glipizide or metformin) by using an double-blind, randomized, parallel control and prospective study The end point of this study is: 1. follow up 3yr 2. recurrence of cardiovascular event 3. death caused by other reasons such as stroke, uremia, blindness and amputation
Interventions
DRUGGlipizide
DRUGMetformin
Sponsors
Shanghai Jiao Tong University School of Medicine
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
No minimum to 80 Years
Healthy volunteers
No
Inclusion criteria
* Coronary heart disease * Type 2 diabetes
Exclusion criteria
* Severe organ dysfunction, psychopathy, infection, neutropenia * Congenital heart disease, rheumatic heart disease, severe arrhythmia, myocardiopathy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite of cardiovascular events which were defined as death from a cardiovascular cause, death from any cause, nonfatal myocardial infarction, nonfatal stroke or arterial revascularization | — |
Secondary
| Measure | Time frame |
|---|---|
| New or worsening angina | — |
| new or worsening heart failure | — |
| new critical cardiac arrhythmia | — |
| new peripheral vascular events | — |
Countries
China
Outcome results
None listed