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Lyspro Insulin vs Regular Insulin in Cirrhotic Patients

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00513201
Enrollment
Unknown
Registered
2007-08-08
Start date
Unknown
Completion date
Unknown
Last updated
2007-08-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Cirrhosis

Keywords

lyspro, regular insulin, cirrhotic patients

Brief summary

OBJECTIVE: To compare lispro insulin and regular insulin in the glycemic control of patients with liver cirrhosis and type 2 diabetes subjects. METHODS: 108 patients with liver cirrhosis and type 2 diabetes were randomly treated with regular insulin or lispro. After 122 weeks a cross-over was carried out and patients followed-up for 122 weeks. Then, all patients received a standard breakfast of 145 kcal following 12 U.I. of regular insulin or lispro, and C-peptide and insulin serum levels were determined over 300 minutes.

Interventions

DRUGlyspro
DRUGregular insulin

Sponsors

University of Campania Luigi Vanvitelli
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Masking
DOUBLE

Eligibility

Sex/Gender
ALL
Age
48 Years to 67 Years

Inclusion criteria

* Insulin-treated diabetes mellitus and liver cirrhosis

Exclusion criteria

* Oral hypoglycemic agents treated diabetes mellitus * Liver cancer

Design outcomes

Primary

MeasureTime frame
Glycemic control in lyspro vs regular insulin treated patients—
Glycemic control in lyspro vs regular insulin in cirrhotic patients—

Secondary

MeasureTime frame
Tolerance to treatment and reduced postprandial hypoglycemia episodes—

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026