Iron Overload, MRI, Sickle Cell Anemia, Sickle Cell Thalassemia
Conditions
Keywords
Sickle Cell Anemia, Sickle Cell Thalassemia, Iron Overload, MRI
Brief summary
Iron overload is well study in Thalassemia patients and it's not only related to blood transfusions, since intestinal iron absorption is also increased in those patients. Sickle cell patients didn't develope significant clinical symptoms and signs of iron overload in spite frequent transfusions. The purpouse of this study is to assess the iron overload in Sickle cell anemia and Sickle cell Thalassemia patients using clinical parameters and cardiac T2\*MRI in order to determine the cardiac and liver iron.
Interventions
OTHERCardiac and Liver T2* MRI
Laboratory examinations that are routinely used in follow up of those patients and T2\* MRI analysis.
Sponsors
Wolfson Medical Center
HaEmek Medical Center, Israel
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* All the patients with Sickle cell anemia and Sickle cell Thalasemia that are currently in follow up at the Pediatric Hematology Unit
Exclusion criteria
* Age below 18 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of Iron overload. | December 2008 |
Secondary
| Measure | Time frame |
|---|---|
| Institute the criteria for iron chelator treatment | December 2008 |
Countries
Israel
Outcome results
None listed