Delirium, Dementia, Amnestic, Cognitive Disorders, Memory Disorders, Postoperative Complications
Conditions
Brief summary
Geriatric patients have a high risk of developing postoperative cognitive deficits. Hypothetical causes are insufficient intraoperative cerebral perfusion or drugs that are administered in the perioperative setting. This study will investigate the role of these two factors in patients aged 65 or older undergoing elective surgical procedures under general aesthesia. Non-invasive techniques will be used to monitor intraoperative cerebral perfusion and anticholinergic activity in the patient's blood is determined. Data will be compared to those of a young (20-40 year old) group of patients undergoing elective surgical procedures using an identical anesthetic technique. A second control group of healthy volunteers older than 65 will be investigated to quantify practice effects with repeated testing of cognitive functions.
Interventions
None listed
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Elective surgical procedure under general anaesthesia
Exclusion criteria
* History of cerebrovascular disease * Mini Mental status \<23 * Cardiac surgery * Neurosurgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in cognitive function due to surgery under general aesthesia | cognitive function measured prior to and after surgery | cognitive function measured by Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neurological test battery |
Countries
Switzerland
Outcome results
None listed