Headache, Migraine, Vasodilatation
Conditions
Keywords
Headache, Migraine, Vasodilatation
Brief summary
We hypothesised that intravenous infusion of PGI2 induced headache or migraine and cranial vasodilatation in migraineurs.
Interventions
DRUGProstacyclin, PGI2
10 ng/kg/min of epoprostenol (stable PGI2)
DRUGPlacebo
NaCL 0,9%
Sponsors
Glostrup University Hospital, Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* migraine without aura and healthy apart from that * age 18-55 years * 50-100 kg * Secure contraceptives
Exclusion criteria
* Tension Type Headache more than 3 time a month * Other primary headaches * Medication prior to the study (closer than 4 times plasma halflife) * Migraine or headache 5 days prior to study. * Hypertension (systolic BP \>150 mmHg and/or diastolic BP \>100 mmHg). * Hypotension (systolic BP \<90 mmHg and/or diastolic BP \<50 mmHg). * Heart-vessel disease of any kind incl cerebrovascular disease. * Anamnestic or clinical signs of psychiatric disease or abuse. * Anamnestic or clinical signs of disease of any kind relevant for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Headache and accompanying symptoms. Blood flow velocity in the middle cerebral artery, diameter changes in superficial temporal artery and radial artery. | 14 hours |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure, pulse | 100 min |
Countries
Denmark
Contacts
Primary ContactTroels Wienecke, MD
Outcome results
None listed