Screening for Gynecologic Cancers in Hereditary Nonpolyposis Colorectal Cancer (HNPCC) Patients

Screening for Gynecologic Cancers Among Women With Hereditary Non-Polyposis Colon Cancer (HNPCC)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00508846

Enrollment

Registered

2007-07-30

Start date

2003-05-31

Completion date

2016-03-31

Last updated

2016-03-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colon Cancer

Keywords

Hereditary Non-Polyposis Colon Cancer, Gynecologic Cancers, Genetic Counseling, Questionnaire, Survey, HNPCC

Brief summary

Among women with HNPCC, this study will assess: 1. Knowledge of screening recommendations for endometrial and ovarian cancers. 2. Perceived risk and cancer worries regarding endometrial, ovarian and colorectal cancers. 3. Adherence to screening recommendations for endometrial, ovarian and colon cancers. 4. Perceived benefits,supports and barriers to endometrial and ovarian cancer screening. 5. Patterns of communication about endometrial and ovarian cancer risk within families with HNPCC and with health care providers. 6. Patient preferences for potential cancer screening and cancer prevention strategies related to HNPCC-associated cancers.

Detailed description

Women who are at risk for HNPCC will be recruited to participate in this pilot study. Women will be invited to participate in the study either through a mailed invitation or during a visit to M.D. Anderson for clinical services or for research purposes. Women who wish to participate in the study will complete an informed consent, and will subsequently schedule an appointment with a research coordinator to complete the study questionnaire by telephone.

Interventions

BEHAVIORALQuestionnaire

Two-part telephone questionnaire lasting about 60 minutes total.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

25 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Being female 2. Being 25 years of age or older 3. Having an HNPCC-predisposing mutation and/or having a family history of cancer that meets the Amsterdam or Amsterdam II criteria for HNPCC

Exclusion criteria

1. Persons who have tested negative for a known HNPCC-predisposing mutation in their family 2. Persons who have no family HNPCC mutation and have not met the Amsterdam I/II criteria 3. Being younger than 25 years old 4. Note: Women who have had a prior history of colorectal cancer or polyps will not be excluded unless they meet one of the above

Design outcomes

Primary

Measure	Time frame	Description
Patient Responses to Questionnaire	7 Years	Outcomes measuring demographics, surveillance behaviors, perceived risk, and cancer worries, screening supports/benefits and barriers.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026