Influenza
Conditions
Brief summary
The present study is designed to evaluate the reactogenicity and immunogenicity of one or two booster administrations of an influenza pandemic candidate vaccine (GSK1562902A) in adults aged between 19 and 61 years, previously vaccinated with 2 doses of a pandemic candidate vaccine. Fifty new subjects who did not participate in a primary study (106750, NCT00309634) will be recruited. This protocol posting deals with objectives & outcome measures of the booster phase. The objectives & outcome measures of the primary phase are presented in a separate protocol posting (NCT00309634)
Detailed description
The present study is designed to evaluate the reactogenicity and immunogenicity of one or two booster administrations of an influenza pandemic candidate vaccine (GSK1562902A) in adults aged between 19 and 61 years, previously vaccinated with 2 doses of a pandemic candidate vaccine. The persistence of antibodies will be analysed at 6, 12, 18 and 24 months.
Interventions
A single dose of Pandemic influenza candidate vaccine (GSK1562902A) administered intramuscularly in the deltoid region of the non-dominant arm at Day 0.
Two doses of Pandemic influenza candidate vaccine (GSK1562902A) administered intramuscularly in the deltoid region of the non-dominant arm at Day 0 and Day 21.
Sponsors
Study design
Eligibility
Inclusion criteria
* Subjects who the investigator believes can and will comply with the requirements of the protocol should be enrolled in the study. * For previously primed subjects: participation in the primary study (NCT00309634). * For unprimed subjects: male or female between and including, 19 and 61 years of age at the time of the first vaccination. * Written informed consent obtained from the subject. * Healthy subjects as established by medical history and clinical examination before entering into the study. * If the subject is female, she must be of non-childbearing potential or if she is of childbearing potential, she must practice adequate contraception for 30 days prior to vaccination, have a negative pregnancy test and continue such precautions for 2 months after completion of the vaccination series.
Exclusion criteria
* Use of any investigational or non-registered product (drug or vaccine) other than the study vaccine(s) within 30 days preceding the first dose of study vaccine, or planned use during the study period. * For unprimed subjects who did not participate in the primary study (NCT00309634): Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within six months prior to the first vaccine dose. * Planned administration/ administration of a licenced vaccine not foreseen by the study protocol within 2 weeks (for inactivated vaccines) or 4 weeks (for live vaccines) of the first dose of vaccine(s). * Concurrently participating in another clinical study, at any time during the study period, in which the subject has been or will be exposed to an investigational or a non-investigational product (pharmaceutical product or device). * Applicable for control group only: previous vaccination with a pandemic candidate vaccine or a vaccine containing the investigational vaccine adjuvant. * History of hypersensitivity to vaccines. * Any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination (no laboratory testing required). * History of allergic disease or reactions likely to be exacerbated by any component of the vaccine(s). * Major congenital defects or serious chronic illness. * History of any neurological disorders or seizures. * Acute disease at the time of enrolment. * Acute or chronic, clinically significant pulmonary, cardiovascular, hepatic or renal functional abnormality, as determined by physical examination or laboratory screening tests. * Serious chronic disease including any medically significant chronic pulmonary, cardiovascular, renal, neurological, psychiatric or metabolic disorder, as determined by medical history and physical examination. * Any condition which, in the opinion of the investigator, prevents the subject from participation in the study. * Lactating female. * History of chronic alcohol consumption and/or drug abuse
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | At Day 0 | Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:10. The flu strain assessed was A/Indonesia/05/2005. |
| Number of Seroconverted Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | At Day 21 | Seroconversion rate for HI antibody response was defined as the percentage of vaccines who have either a pre-vaccination titer \< 1:10 and a post-vaccination titer ≥ 1:40 or a pre-vaccination titer ≥ 1:10 and at least a 4-fold increase in post-vaccination titer. |
| Seroconversion Factor (SCF) for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | At Day 21 | Seroconversion factor (SCF) was defined as the fold increase in H5N1 HI antibody GMTs post-vaccination compared to Day 0. The flu strain assessed was A/Indonesia/05/2005. |
| Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | At Day 0 | A seroprotected subject was defined as a vaccinated subject with a serum HI titer equal to or above (≥) 1:40. The flu strain assessed was A/Indonesia/05/2005. |
| Number of Subjects With Any and Grade 3 Solicited Local Symptoms | During the 7-day (Days 0-6) post-vaccination period following each dose and across doses | Assessed solicited local symptoms were ecchymosis, induration, pain, redness and swelling. Any = occurrence of the symptom regardless of intensity grade. Grade 3 pain = pain that prevented normal activity. Grade 3 ecchymosis/induration/redness/swelling = redness/swelling spreading beyond 100 millimeters (mm) of injection site. No subject from GSK1562902A AD F1 Primed Group has received Dose 2. |
| Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | During the 7-day (Days 0-6) post-vaccination period following each dose and across doses | Assessed solicited general symptoms were arthralgia, fatigue, headache, myalgia, shivering, sweating and fever \[defined as axillary temperature equal to or above (≥) 38 degrees Celsius (°C)\]. Any = occurrence of the symptom regardless of intensity grade. Grade 3 symptom = symptom that prevented normal activity. Grade 3 fever = fever ≥ 39.0 °C. Related = symptom assessed by the investigator as causally related to the study vaccination. No subject from GSK1562902A AD F1 Primed Group has received Dose 2. |
| Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | During the 21-day (Days 0-20) follow-up period after the first vaccination and 30-day (Days 0-29) follow-up period after the second vaccination | An unsolicited AE covers any untoward medical occurrence in a clinical investigation subject temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product and reported in addition to those solicited during the clinical study and any solicited symptom with onset outside the specified period of follow-up for solicited symptoms. Any was defined as the occurrence of any unsolicited AE regardless of intensity grade or relation to vaccination. Grade 3 AE = an AE which prevented normal, everyday activities. Related = AE assessed by the investigator as related to the vaccination. |
| Number of Subjects With Serious Adverse Events (SAEs) | During the entire study period (From Day 0 up to Month 24) | SAEs assessed include medical occurrences that result in death, are life-threatening, require hospitalization or prolongation of hospitalization or result in disability/incapacity. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | At Days 0, 21 (post-vaccination one) and 42 (post-vaccination two) | Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:28. The flu strain assessed was A/Indonesia/05/2005. No subject from GSK1562902A AD F1 Primed Group has received a second vaccination. |
| Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | At Days 0 and 21 | Among cytokines expressed after background reduction were cluster of differentiation 4 all doubles (CD4 all doubles), cluster of differentiation 40-ligand (CD40-L), interleukin-2 (IL-2), interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α). The flu strains assessed wwere H5N1 A/Indonesia and H5N1 A/Vietnam. |
| Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | At Months 6, 12, 18 and 24 | Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:28. The flu strain assessed was A/Indonesia/05/2005. |
| Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | At Days 0, 7, 14, 21, 28, 35 and 42 | Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:10. The flu strain assessed was A/Indonesia/05/2005. |
| Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | At Months 6, 12, 18 and 24 | Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:10. The flu strain assessed was A/Indonesia/05/2005. |
| Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | At Days 7,14, 21, 35 and 42 | Seroconversion (SCR) was defined as the proportion of subjects who had either a pre-vaccination reciprocal HI titer \< 10 and a post-vaccination reciprocal titer ≥ 40, or a pre-vaccination reciprocal HI titer ≥ 10 and at least a 4-fold increase in post-vaccination reciprocal titer against the vaccine virus. The flu strain assessed was Flu A/Indonesia/05/2005. |
| Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | At Days 21 (post-vaccination one) and 42 (post-vaccination two) | Seroconversion rate for anti-HA antibody response was defined as the percentage of vaccines who have either a pre-vaccination titer \< 1:40 and a post-vaccination titer ≥ 1:56 or a pre-vaccination titer ≥ 1:56 and at least a 4-fold increase in post-vaccination titer. |
| Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | At Days 7, 14, 21, 35 and 42 | Seroconversion factor (SCF) was defined as the fold increase in H5N1 HI antibody GMTs post-vaccination compared to Day 0. The flu strain assessed was A/Indonesia/05/2005. |
| Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | At Days 0, 7, 14, 21, 28, 35 and 42 | Seroprotection rate was defined as the percentage of vaccines with a serum HI antibody titer ≥ 1:40 that usually is accepted as indicating protection. The flu strain assessed was A/Indonesia/05/2005 (H5N1). |
Countries
Belgium
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| GSK1562902A Non-AD F1 Primed Group Healthy male or female adults, between and including 19 to 61 years of age, primed with 2 doses of a non-adjuvanted (non-AD) investigational H5N1 vaccine (A/Vietnam/1194/04 strain) Formulation 1 (F1) in study 106750 (NCT00309634) receiving 2 doses of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study, one at Day 0 and one at Day 21, administrated intramuscularly (IM) in the deltoid region of the non-dominant arm. | 36 |
| GSK1562902A Non-AD F2 Primed Group Healthy male or female adults, between and including 19 to 61 years of age, primed with 2 doses of a non-adjuvanted (non-AD) investigational H5N1 vaccine (A/Vietnam/1194/04 strain) Formulation 2 (F2) in study 106750 (NCT00309634) receiving 2 doses of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study, one at Day 0 and one at Day 21, administrated IM in the deltoid region of the non-dominant arm. | 40 |
| GSK1562902A Non-AD F3 Primed Group Healthy male or female adults, between and including 19 to 61 years of age, primed with 2 doses of a non-adjuvanted (non-AD) investigational H5N1 vaccine (A/Vietnam/1194/04 strain) Formulation 3 (F3) in study 106750 (NCT00309634) receiving 2 doses of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study, one at Day 0 and one at Day 21, administrated IM in the deltoid region of the non-dominant arm. | 37 |
| GSK1562902A Non-AD F4 Primed Group Healthy male or female adults, between and including 19 to 61 years of age, primed with 2 doses of a non-adjuvanted (non-AD) investigational H5N1 vaccine (A/Vietnam/1194/04 strain) Formulation 4 (F4) in study 106750 (NCT00309634) receiving 2 doses of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study, one at Day 0 and one at Day 21, administrated IM in the deltoid region of the non-dominant arm. | 36 |
| Control Group Healthy male or female adults, between and including 19 to 61 years of age, unprimed receiving 2 doses of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study, one at Day 0 and one at Day 21, administrated IM in the deltoid region of the non-dominant arm. | 50 |
| GSK1562902A AD F1 Primed Group Healthy male or female adults, between and including 19 to 61 years of age, primed with 2 doses of an adjuvanted (AD) investigational H5N1 vaccine (A/Vietnam/1194/04 strain) Formulation1 (F1) in study 106750 (NCT00309634) received 1 dose of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study at Day 0, administrated IM in the deltoid region of the non-dominant arm. | 40 |
| GSK1562902A AD F2 Primed Group Healthy male or female adults, between and including 19 to 61 years of age, primed with 2 doses of an adjuvanted (AD) investigational H5N1 vaccine (A/Vietnam/1194/04 strain) Formulation 2 (F2) in study 106750 (NCT00309634) received 1 dose of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study at Day 0, administrated IM in the deltoid region of the non-dominant arm. | 35 |
| GSK1562902A AD F3 Primed Group Healthy male or female adults, between and including 19 to 61 years of age, primed with 2 doses of an adjuvanted (AD) investigational H5N1 vaccine (A/Vietnam/1194/04 strain) Formulation 3 (F3)in study 106750 (NCT00309634) received 1 dose of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study at Day 0, administrated IM in the deltoid region of the non-dominant arm. | 41 |
| GSK1562902A AD Approved F Primed Group Healthy male or female adults, between and including 19 to 61 years of age, primed with 2 doses of approved Formulation (F) of adjuvanted (AD) H5N1 vaccine (A/Vietnam/1194/04 strain) in study 106750 (NCT00309634) received 1 dose of Pandemic influenza candidate vaccine (GSK1562902A) in this booster study at Day 0, administrated IM in the deltoid region of the non-dominant arm. | 35 |
| Total | 350 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 | FG002 | FG003 | FG004 | FG005 | FG006 | FG007 | FG008 |
|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study | Adverse Event | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
| Overall Study | Lost to Follow-up | 1 | 1 | 1 | 1 | 2 | 1 | 0 | 0 | 2 |
| Overall Study | Medical Reason | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
| Overall Study | Other | 1 | 1 | 3 | 0 | 3 | 0 | 0 | 2 | 2 |
| Overall Study | Protocol Violation | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
| Overall Study | Serious Adverse Event | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Overall Study | Withdrawal by Subject | 0 | 1 | 1 | 1 | 4 | 1 | 1 | 2 | 0 |
Baseline characteristics
| Characteristic | GSK1562902A Non-AD F1 Primed Group | GSK1562902A Non-AD F2 Primed Group | GSK1562902A Non-AD F3 Primed Group | GSK1562902A Non-AD F4 Primed Group | Control Group | GSK1562902A AD F1 Primed Group | GSK1562902A AD F2 Primed Group | GSK1562902A AD F3 Primed Group | GSK1562902A AD Approved F Primed Group | Total |
|---|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | 36.3 Years STANDARD_DEVIATION 12.8 | 36.3 Years STANDARD_DEVIATION 12.36 | 36.8 Years STANDARD_DEVIATION 12.87 | 39.5 Years STANDARD_DEVIATION 13.27 | 32.1 Years STANDARD_DEVIATION 9.96 | 38.5 Years STANDARD_DEVIATION 13.43 | 38.3 Years STANDARD_DEVIATION 14.61 | 34.8 Years STANDARD_DEVIATION 14.57 | 35.9 Years STANDARD_DEVIATION 12.78 | 36.32 Years STANDARD_DEVIATION 12.97 |
| Race/Ethnicity, Customized Race Other | 0 Participants | 2 Participants | 0 Participants | 0 Participants | 1 Participants | 0 Participants | 1 Participants | 0 Participants | 0 Participants | 4 Participants |
| Race/Ethnicity, Customized Race White - Arabic / North African heritage | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 1 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 1 Participants |
| Race/Ethnicity, Customized Race White - Caucasian / European heritage | 36 Participants | 38 Participants | 37 Participants | 36 Participants | 48 Participants | 40 Participants | 34 Participants | 41 Participants | 35 Participants | 345 Participants |
| Sex: Female, Male Female | 18 Participants | 19 Participants | 16 Participants | 21 Participants | 34 Participants | 27 Participants | 18 Participants | 23 Participants | 18 Participants | 194 Participants |
| Sex: Female, Male Male | 18 Participants | 21 Participants | 21 Participants | 15 Participants | 16 Participants | 13 Participants | 17 Participants | 18 Participants | 17 Participants | 156 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk | EG004 affected / at risk | EG005 affected / at risk | EG006 affected / at risk | EG007 affected / at risk | EG008 affected / at risk |
|---|---|---|---|---|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 36 | 0 / 40 | 0 / 37 | 0 / 36 | 0 / 50 | 0 / 40 | 0 / 35 | 1 / 41 | 1 / 35 |
| other Total, other adverse events | 34 / 36 | 40 / 40 | 33 / 37 | 35 / 36 | 48 / 50 | 39 / 40 | 34 / 35 | 41 / 41 | 33 / 35 |
| serious Total, serious adverse events | 4 / 36 | 3 / 40 | 2 / 37 | 0 / 36 | 4 / 50 | 2 / 40 | 1 / 35 | 4 / 41 | 3 / 35 |
Outcome results
Number of Seroconverted Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain
Seroconversion rate for HI antibody response was defined as the percentage of vaccines who have either a pre-vaccination titer \< 1:10 and a post-vaccination titer ≥ 1:40 or a pre-vaccination titer ≥ 1:10 and at least a 4-fold increase in post-vaccination titer.
Time frame: At Day 21
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroconverted Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 36 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 33 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 34 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 31 Participants |
Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain
A seroprotected subject was defined as a vaccinated subject with a serum HI titer equal to or above (≥) 1:40. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Day 0
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 0 Participants |
Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain
A seroprotected subject was defined as a vaccinated subject with a serum HI titer equal to or above (≥) 1:40. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Day 21
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 36 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 33 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 34 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected Subjects for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 31 Participants |
Number of Subjects With Any and Grade 3 Solicited Local Symptoms
Assessed solicited local symptoms were ecchymosis, induration, pain, redness and swelling. Any = occurrence of the symptom regardless of intensity grade. Grade 3 pain = pain that prevented normal activity. Grade 3 ecchymosis/induration/redness/swelling = redness/swelling spreading beyond 100 millimeters (mm) of injection site. No subject from GSK1562902A AD F1 Primed Group has received Dose 2.
Time frame: During the 7-day (Days 0-6) post-vaccination period following each dose and across doses
Population: The analysis was performed on the Total Vaccinated cohort, which included all vaccinated subjects for whom data were available and who had their symptom sheets filled in.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 2 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 33 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 4 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 34 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 6 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 2 | 28 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 2 | 3 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 2 | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 36 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 35 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 2 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 2 | 30 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 4 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 2 | 2 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 32 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 2 | 24 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 2 | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 32 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 6 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 34 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 2 | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 2 | 28 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 35 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 2 | 5 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 2 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 1 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 45 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 2 | 2 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 6 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 47 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 2 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 2 | 1 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 2 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 6 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 2 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 2 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 3 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 2 | 5 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 2 | 4 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 1 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 2 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 3 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 1 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 2 | 42 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 3 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 1 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| Control Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 2 | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 38 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 38 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 4 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 3 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 34 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 3 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 2 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 2 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 2 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 2 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 34 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 4 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 3 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 39 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 39 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Across doses | 31 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 2 | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Dose 1 | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Across doses | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Redness, Dose 1 | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Pain, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Redness, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Pain, Dose 1 | 31 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Induration, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Dose 1 | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Swelling, Across doses | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Ecchymosis, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Grade 3 Swelling, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Induration, Across doses | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any and Grade 3 Solicited Local Symptoms | Any Ecchymosis, Across doses | 0 Participants |
Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms
Assessed solicited general symptoms were arthralgia, fatigue, headache, myalgia, shivering, sweating and fever \[defined as axillary temperature equal to or above (≥) 38 degrees Celsius (°C)\]. Any = occurrence of the symptom regardless of intensity grade. Grade 3 symptom = symptom that prevented normal activity. Grade 3 fever = fever ≥ 39.0 °C. Related = symptom assessed by the investigator as causally related to the study vaccination. No subject from GSK1562902A AD F1 Primed Group has received Dose 2.
Time frame: During the 7-day (Days 0-6) post-vaccination period following each dose and across doses
Population: The analysis was performed on the Total Vaccinated cohort, which included all vaccinated subjects for whom data were available and who had their symptom sheets filled in.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 17 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 2 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 17 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 2 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 2 | 9 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 18 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 10 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 2 | 11 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 20 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 9 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 4 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 2 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 2 | 6 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 2 | 7 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 2 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 2 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 9 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 4 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 2 | 6 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 2 | 7 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 2 | 13 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 2 | 14 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 2 | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 13 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 3 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 2 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 10 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 11 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 17 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 10 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 2 | 11 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 14 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 20 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 4 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 7 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 2 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 2 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 2 | 4 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 2 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 2 | 12 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 15 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 2 | 10 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 2 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 17 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 3 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 18 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 3 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 20 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 16 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 12 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 7 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 2 | 3 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 18 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 21 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 15 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 8 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 11 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 2 | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 17 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 2 | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 15 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 2 | 3 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 4 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 2 | 8 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 4 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 2 | 9 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 2 | 9 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 2 | 4 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 2 | 10 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 2 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 12 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 15 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 2 | 8 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 4 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 2 | 12 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 11 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 4 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 2 | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 2 | 9 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 14 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 14 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 2 | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 14 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 2 | 4 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 2 | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 15 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 2 | 4 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 2 | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 2 | 9 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 2 | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 2 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 2 | 9 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 15 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 15 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 20 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 20 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 2 | 13 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 7 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 2 | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 2 | 9 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 11 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 2 | 13 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 2 | 7 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 2 | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 14 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 10 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 2 | 6 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 2 | 6 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 2 | 6 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 10 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 5 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 15 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 2 | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 10 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 7 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 12 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 14 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 2 | 9 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 2 | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 10 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 14 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 13 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 15 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 5 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 2 | 3 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 18 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 2 | 24 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 2 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 4 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 1 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 7 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 24 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 2 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 22 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 9 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 2 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 14 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 3 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 11 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 2 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 17 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 7 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 2 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 6 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 10 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 0 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 6 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 2 | 10 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 2 | 0 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 2 | 10 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 2 | 25 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 2 | 4 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 2 | 0 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 2 | 4 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 2 | 23 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 2 | 3 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 2 | 19 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 2 | 24 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 2 | 0 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 2 | 22 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 2 | 14 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 2 | 1 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 2 | 14 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 2 | 10 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 2 | 1 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 2 | 10 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 14 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 13 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 30 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 5 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 29 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 4 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 28 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 4 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 22 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 30 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 2 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 28 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 20 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 3 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 19 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 13 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 9 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 6 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 15 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 11 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 19 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 9 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 6 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 11 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 16 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 15 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 16 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 9 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 19 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 15 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 9 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 15 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 12 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 9 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 10 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 10 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 9 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 9 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 10 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 10 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 11 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 12 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 11 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 6 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 9 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 11 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 18 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 4 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 11 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 2 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 4 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 9 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 6 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 11 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 10 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 10 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 3 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 2 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 11 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 2 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 9 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 18 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Across doses | 10 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 1 | 5 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 1 | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Across doses | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Across doses | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Across doses | 12 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 1 | 10 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Across doses | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Across doses | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Shivering, Dose 1 | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fatigue, Dose 1 | 12 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Dose 1 | 9 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 1 | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Arthralgia, Across doses | 5 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Myalgia, Across doses | 9 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Across doses | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Dose 1 | 9 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Headache, Across doses | 9 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fatigue, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fever, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Myalgia, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Fever, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Across doses | 13 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Headache, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Fever, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Any Fatigue, Dose 1 | 13 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Sweating, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Shivering, Dose 1 | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Across doses | 8 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Dose 2 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Sweating, Dose 1 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 1 | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Headache, Dose 1 | 8 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Shivering, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Grade 3 Arthralgia, Across doses | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Solicited General Symptoms | Related Arthralgia, Dose 2 | 0 Participants |
Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs)
An unsolicited AE covers any untoward medical occurrence in a clinical investigation subject temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product and reported in addition to those solicited during the clinical study and any solicited symptom with onset outside the specified period of follow-up for solicited symptoms. Any was defined as the occurrence of any unsolicited AE regardless of intensity grade or relation to vaccination. Grade 3 AE = an AE which prevented normal, everyday activities. Related = AE assessed by the investigator as related to the vaccination.
Time frame: During the 30-day (Days 0-29) follow-up period after the first vaccination
Population: The analysis was performed on the Total Vaccinated cohort, which included all vaccinated subjects for whom data were available.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 3 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 13 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 4 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 5 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 17 Participants |
Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs)
An unsolicited AE covers any untoward medical occurrence in a clinical investigation subject temporally associated with the use of a medicinal product, whether or not considered related to the medicinal product and reported in addition to those solicited during the clinical study and any solicited symptom with onset outside the specified period of follow-up for solicited symptoms. Any was defined as the occurrence of any unsolicited AE regardless of intensity grade or relation to vaccination. Grade 3 AE = an AE which prevented normal, everyday activities. Related = AE assessed by the investigator as related to the vaccination.
Time frame: During the 21-day (Days 0-20) follow-up period after the first vaccination and 30-day (Days 0-29) follow-up period after the second vaccination
Population: The analysis was performed on the Total Vaccinated cohort, which included all vaccinated subjects for whom data were available.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 22 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 4 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 4 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 24 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 21 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 4 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 26 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 3 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Grade 3 AE(s) | 6 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Any AE(s) | 33 Participants |
| Control Group | Number of Subjects With Any, Grade 3 and Related Unsolicited Adverse Events (AEs) | Related AE(s) | 8 Participants |
Number of Subjects With Serious Adverse Events (SAEs)
SAEs assessed include medical occurrences that result in death, are life-threatening, require hospitalization or prolongation of hospitalization or result in disability/incapacity.
Time frame: During the entire study period (From Day 0 up to Month 24)
Population: The analysis was performed on the Total Vaccinated cohort, which included all vaccinated subjects for whom data were available.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 2 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 1 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 0 Participants |
| Control Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 3 Participants |
| Control Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 0 Participants |
| Control Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 0 Participants |
| Control Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 1 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 1 Participants |
| GSK1562902A AD F3 Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 1 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 12 - Month 18 | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 6 - Month 12 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Month 18 - Month 24 | 2 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Subjects With Serious Adverse Events (SAEs) | Day 0 - Month 6 | 0 Participants |
Seroconversion Factor (SCF) for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain
Seroconversion factor (SCF) was defined as the fold increase in H5N1 HI antibody GMTs post-vaccination compared to Day 0. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Day 21
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Value (GEOMETRIC_MEAN) |
|---|---|---|
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 79.9 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 76.5 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 39.1 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | 76.9 Fold increase |
Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain
Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:10. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Day 21
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Value (GEOMETRIC_MEAN) |
|---|---|---|
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | 406.8 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | 429.5 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | 208.4 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | 347.9 Titers |
Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain
Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:10. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Day 0
Population: The analysis was performed on the According-to-Protocol (ATP) cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Value (GEOMETRIC_MEAN) |
|---|---|---|
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | 5.1 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | 5.6 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | 5.3 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemagglutinin Inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | 5.2 Titers |
Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines
Among cytokines expressed after background reduction were cluster of differentiation 4 all doubles (CD4 all doubles), cluster of differentiation 40-ligand (CD40-L), interleukin-2 (IL-2), interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α). The flu strains assessed were H5N1 A/Indonesia and H5N1 A/Vietnam.
Time frame: At Months 6, 12, 18 and 24
Population: The analysis was performed on the ATP cohort for persistence, which consisted of all subjects who had serologic results available at the antibody persistence time point.
| Arm | Measure | Group | Value (MEDIAN) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 6 | 1575.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 6 | 1454.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 12 | 1183.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 18 | 1042.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 18 | 1173.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 24 | 1220.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 24 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 6 | 1710.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 6 | 1605.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 6 | 1724.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 6 | 1481.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 6 | 794.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 6 | 876.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 6 | 1152.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 6 | 1279.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 12 | 1333.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 12 | 1171.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 12 | 1119.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 12 | 1090.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 12 | 1290.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 12 | 746.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 12 | 670.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 12 | 1065.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 12 | 945.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 18 | 1421.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 18 | 1536.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 18 | 1369.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 18 | 1523.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 18 | 1316.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 18 | 1346.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 18 | 906.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 18 | 1074.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 24 | 1307.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 24 | 1229.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 24 | 1195.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 24 | 1146.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 24 | 1101.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 24 | 848.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 24 | 838.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 24 | 1062.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 24 | 999.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 6 | 59.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 6 | 85.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 6 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 6 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 6 | 52.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 6 | 93.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 6 | 29.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 6 | 48.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 6 | 52.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 6 | 73.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 12 | 78.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 12 | 69.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 12 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 12 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 12 | 56.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 12 | 55.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 12 | 46.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 12 | 77.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 12 | 54.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 12 | 55.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 18 | 35.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 18 | 48.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 18 | 38.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 18 | 48.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 18 | 38.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 24 | 78.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 24 | 29.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 24 | 26.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 24 | 21.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 24 | 1.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 24 | 64.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 24 | 31.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 24 | 26.00 T-cell/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 24 | 37.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 12 | 95.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 6 | 1244.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 18 | 66.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 18 | 65.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 12 | 1.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 18 | 43.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 24 | 773.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 24 | 704.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 24 | 914.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 24 | 680.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 18 | 82.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 18 | 729.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 12 | 1.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 24 | 26.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 6 | 79.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 24 | 850.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 18 | 40.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 6 | 1138.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 6 | 139.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 24 | 73.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 6 | 1190.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 18 | 946.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 12 | 54.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 6 | 1124.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 24 | 917.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 6 | 1136.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 6 | 1.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 18 | 743.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 6 | 1070.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 24 | 57.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 6 | 1.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 6 | 636.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 18 | 82.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 12 | 49.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 6 | 679.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 24 | 826.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 6 | 54.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 6 | 920.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 18 | 811.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 24 | 45.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 6 | 941.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 6 | 77.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 12 | 60.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 12 | 786.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 24 | 867.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 18 | 62.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 12 | 796.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 6 | 49.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 24 | 73.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 12 | 647.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 24 | 1.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 12 | 54.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 12 | 641.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 6 | 117.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 12 | 721.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 24 | 839.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 12 | 733.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 18 | 933.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 24 | 73.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 12 | 432.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 6 | 71.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 12 | 62.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 12 | 497.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 18 | 793.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 18 | 81.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 12 | 551.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 6 | 123.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 24 | 1.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 12 | 616.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 24 | 654.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 12 | 75.50 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 18 | 1052.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 18 | 1036.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 12 | 73.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 18 | 1022.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 24 | 25.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 24 | 93.00 T-cell/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 18 | 1013.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 12 | 1100.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 18 | 1288.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 18 | 40.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 18 | 1170.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 18 | 1062.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 18 | 865.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 18 | 965.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 18 | 1035.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 18 | 119.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 18 | 1079.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 24 | 1.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 24 | 1306.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 24 | 1322.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 24 | 1280.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 24 | 1356.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 24 | 1105.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 24 | 1253.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 18 | 1.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 24 | 860.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 24 | 888.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 18 | 30.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 24 | 1023.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 24 | 32.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 6 | 89.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 6 | 107.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 18 | 47.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 6 | 1.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 6 | 1.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 18 | 31.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 6 | 53.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 24 | 31.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 6 | 63.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 6 | 44.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 18 | 119.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 6 | 61.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 24 | 55.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 6 | 76.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 6 | 80.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 18 | 42.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 12 | 30.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 12 | 31.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 12 | 1.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 24 | 65.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 24 | 1186.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 18 | 107.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Month 24 | 102.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 24 | 102.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 6 | 1817.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Month 12 | 1.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 6 | 1775.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 6 | 1720.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 6 | 1748.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 6 | 1736.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Month 12 | 5.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Month 6 | 1580.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Month 24 | 65.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 6 | 929.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 6 | 885.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Month 12 | 13.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 6 | 1467.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 24 | 64.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 6 | 1292.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 12 | 1332.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Month 12 | 1.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 12 | 1225.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 12 | 1159.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Month 12 | 1134.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Month 12 | 32.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Month 12 | 1219.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Month 18 | 1330.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Month 12 | 618.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Month 12 | 643.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Month 12 | 23.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Month 12 | 997.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Month 12 | 939.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Month 18 | 1392.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Month 12 | 31.50 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Month 18 | 1367.00 T-cell/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Month 24 | 1.00 T-cell/million cells |
Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines
Among cytokines expressed after background reduction were cluster of differentiation 4 all doubles (CD4 all doubles), cluster of differentiation 40-ligand (CD40-L), interleukin-2 (IL-2), interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α). The flu strains assessed wwere H5N1 A/Indonesia and H5N1 A/Vietnam.
Time frame: At Days 0 and 21
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Group | Value (MEDIAN) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Day 0 | 42.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Day 0 | 407.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Day 0 | 682.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Day 21 | 785.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Day 0 | 490.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Day 21 | 1.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Day 0 | 470.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Day 0 | 71.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Day 0 | 1.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Day 21 | 960.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Day 0 | 80.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Day 21 | 1.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Day 0 | 544.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Day 21 | 1870.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Day 0 | 1.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Day 21 | 1187.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Day 21 | 150.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Day 21 | 166.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Day 21 | 1874.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Day 0 | 159.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Day 21 | 1360.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Day 0 | 709.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Day 21 | 132.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Day 0 | 152.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Day 0 | 650.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Day 0 | 743.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Day 21 | 132.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Day 21 | 1842.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Day 21 | 1607.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Day 0 | 92.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Day 0 | 641.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Day 0 | 98.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Day 21 | 86.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Day 21 | 1616.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Day 21 | 1945.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Day 0 | 59.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Day 0 | 599.50 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Day 21 | 115.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Day 21 | 31.00 T-cells/million cells |
| GSK1562902A AD F1 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Day 21 | 124.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Day 21 | 39.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Day 0 | 1.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Day 21 | 127.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Day 0 | 1370.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Day 21 | 2504.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Day 0 | 1284.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Day 21 | 2640.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Day 0 | 1363.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Day 21 | 2480.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Day 0 | 1288.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Day 21 | 2652.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Day 0 | 1186.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Day 21 | 2291.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Day 0 | 1195.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Day 21 | 2210.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Day 0 | 607.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Day 21 | 1304.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Day 0 | 729.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Day 21 | 1105.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Day 0 | 944.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Day 21 | 1905.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Day 0 | 952.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Day 21 | 1888.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Day 0 | 60.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Day 21 | 75.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Day 0 | 99.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Day 21 | 153.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Day 21 | 1.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Day 0 | 1.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Day 21 | 1.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Day 0 | 40.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Day 0 | 48.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Day 21 | 90.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Day 0 | 40.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Day 21 | 56.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Day 0 | 76.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Day 0 | 47.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Day 21 | 75.50 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Day 0 | 83.00 T-cells/million cells |
| GSK1562902A AD F2 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Day 21 | 98.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Day 21 | 2607.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Day 0 | 1.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Day 21 | 993.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Day 0 | 71.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Vietnam, Day 21 | 1.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Day 21 | 2368.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Day 0 | 28.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Day 0 | 30.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Vietnam, Day 0 | 473.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Vietnam, Day 0 | 540.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Indonesia, Day 21 | 39.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Day 21 | 2485.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Day 21 | 2721.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Day 0 | 51.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 IL-2 - H5N1 A/Indonesia, Day 0 | 433.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Indonesia, Day 0 | 357.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 IL-2 - H5N1 A/Vietnam, Day 21 | 86.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Day 21 | 2580.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Indonesia, Day 21 | 36.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Day 0 | 37.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Vietnam, Day 0 | 525.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 ALL DOUBLES - H5N1 A/Indonesia, Day 0 | 473.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Indonesia, Day 21 | 41.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Day 21 | 2633.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Day 0 | 47.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Day 21 | 1616.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 TNF-α - H5N1 A/Vietnam, Day 21 | 136.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Indonesia, Day 21 | 52.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Vietnam, Day 0 | 357.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Day 0 | 97.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Day 0 | 90.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Day 21 | 1658.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 CD40L - H5N1 A/Indonesia, Day 0 | 457.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 ALL DOUBLES - H5N1 A/Vietnam, Day 21 | 147.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 TNF-α - H5N1 A/Indonesia, Day 0 | 294.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Day 0 | 1.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Day 21 | 1057.50 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 INF-γ - H5N1 A/Vietnam, Day 21 | 149.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD8 CD40L - H5N1 A/Indonesia, Day 21 | 1.00 T-cells/million cells |
| GSK1562902A AD F3 Primed Group | Frequency of Antigen-specific CD4/CD8 T-cells (Per 10E6) in Tests Identified as Producing at Least Two Out of Four Different Cytokines | CD4 INF-γ - H5N1 A/Vietnam, Day 0 | 406.50 T-cells/million cells |
Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain
Seroconversion (SCR) was defined as the proportion of subjects who had either a pre-vaccination reciprocal HI titer \< 10 and a post-vaccination reciprocal titer ≥ 40, or a pre-vaccination reciprocal HI titer ≥ 10 and at least a 4-fold increase in post-vaccination reciprocal titer against the vaccine virus. The flu strain assessed was Flu A/Indonesia/05/2005.
Time frame: At Days 7,14, 21, 35 and 42
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 21 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 22 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 19 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 22 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 12 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 27 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 33 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 17 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 28 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 34 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 19 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 18 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 19 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 23 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 23 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 23 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 27 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 21 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 17 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 27 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 48 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 12 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 0 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 29 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 49 Participants |
Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain
SCR was defined as the proportion of subjects who had either a pre-vaccination reciprocal HI titer\< 10 and a post-vaccination reciprocal titer ≥ 40, or a pre-vaccination reciprocal HI titer ≥ 10 and at least a 4-fold increase in post-vaccination reciprocal titer against the vaccine virus. The flu strain assessed was Flu A/Indonesia/05/2005.
Time frame: At Months 6, 12, 18 and 24
Population: The analysis was performed on the ATP cohort for persistence, which consisted of all subjects who had serologic results available at the antibody persistence time point.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 8 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 7 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 12 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 12 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 13 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 7 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 15 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 15 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 13 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 3 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 14 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 19 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 5 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 15 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 5 Participants |
| Control Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 16 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 26 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 18 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 27 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 21 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 16 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 24 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 20 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 24 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 16 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 20 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 27 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 22 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 21 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 23 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 24 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroconverted (SCR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 11 Participants |
Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain
Seroconversion rate for anti-HA antibody response was defined as the percentage of vaccines who have either a pre-vaccination titer \< 1:40 and a post-vaccination titer ≥ 1:56 or a pre-vaccination titer ≥ 1:56 and at least a 4-fold increase in post-vaccination titer.
Time frame: At Days 21 (post-vaccination one) and 42 (post-vaccination two)
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 29 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 31 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 35 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 44 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 49 Participants |
Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain
Seroconversion rate for neutralizing antibody response was defined as the percentage of vaccines who have either a pre-vaccination titer \< 1:40 and a post-vaccination titer ≥ 1:56 or a pre-vaccination titer ≥ 1:56 and at least a 4-fold increase in post-vaccination titer.
Time frame: At Months 6, 12, 18 and 24
Population: The analysis was performed on the ATP cohort for persistence, which consisted of all subjects who had serologic results available at the antibody persistence time point.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 29 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 17 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 21 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 13 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 13 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 29 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 19 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 14 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 29 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 41 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 35 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroconverted (SCR) Subjects for Neutralizing HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 44 Participants |
Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain
Seroprotection rate was defined as the percentage of vaccines with a serum HI antibody titer ≥ 1:40 that usually is accepted as indicating protection. The flu strain assessed was A/Indonesia/05/2005 (H5N1).
Time frame: At Days 0, 7, 14, 21, 28, 35 and 42
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 0 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 22 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 22 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 21 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 22 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 19 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 34 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 0 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 17 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 28 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 27 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 32 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 33 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 19 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 23 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 19 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 22 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 0 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 23 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 18 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 17 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 21 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 26 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 0 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 27 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 27 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 23 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 48 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 49 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 0 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 29 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 12 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 0 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 49 Participants |
Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain
Seroprotection rate was defined as the percentage of vaccines with a serum HI antibody titer ≥ 1:40 that usually is accepted as indicating protection. The flu strain assessed was A/Indonesia/05/2005 (H5N1).
Time frame: At Months 6, 12, 18 and 24
Population: The analysis was performed on the ATP cohort for persistence, which consisted of all subjects who had serologic results available at the antibody persistence time point.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 8 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 12 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 7 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 13 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 5 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 12 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 17 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 15 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 15 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 7 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 17 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 19 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 14 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 13 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 3 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 5 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 15 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 16 Participants |
| Control Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 5 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 22 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 27 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 19 Participants |
| GSK1562902A AD F1 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 28 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 25 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 16 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 25 Participants |
| GSK1562902A AD F2 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 20 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 22 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 20 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 27 Participants |
| GSK1562902A AD F3 Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 16 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 24 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 21 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 11 Participants |
| GSK1562902A AD Approved F Primed Group | Number of Seroprotected (SPR) Subjects for HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 23 Participants |
Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain
Seroconversion factor (SCF) was defined as the fold increase in H5N1 HI antibody GMTs post-vaccination compared to Day 0. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Days 7, 14, 21, 35 and 42
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Group | Value (GEOMETRIC_MEAN) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 7.4 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 11.0 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 4.3 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 10.6 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 9.1 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 24.0 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 13.2 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 5.1 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 11.5 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 23.3 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 13.2 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 12.7 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 5.5 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 9.8 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 8.4 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 32.0 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 15.4 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 7.5 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 28.3 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 14.3 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 88.6 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 1.0 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 6.2 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 112.7 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 2.7 Fold increase |
Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain
Seroconversion factor (SCF) was defined as the fold increase in H5N1 HI antibody GMTs post-vaccination compared to Day 0. The flu strains assessed were A/Indonesia/05/2005.
Time frame: At Months 6, 12, 18 and 24
Population: The analysis was performed on the ATP cohort for persistence, which consisted of all subjects who had serologic results available at the antibody persistence time point.
| Arm | Measure | Group | Value (GEOMETRIC_MEAN) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 3.4 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 3.8 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 2.6 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 1.9 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 1.8 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 3.3 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 3.3 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 4.6 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 4.5 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 1.9 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 4.1 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 3.7 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 4.9 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 3.8 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 6.7 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 1.7 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 2.4 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 3.2 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 3.6 Fold increase |
| Control Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 2.2 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 6.9 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 15.0 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 10.1 Fold increase |
| GSK1562902A AD F1 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 18.3 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 11.5 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 18.3 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 5.9 Fold increase |
| GSK1562902A AD F2 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 14.1 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 11.2 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 4.1 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 7.9 Fold increase |
| GSK1562902A AD F3 Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 7.9 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 9.8 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 4.7 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 11.6 Fold increase |
| GSK1562902A AD Approved F Primed Group | Seroconversion Factor (SCF) for H5N1 Haemagglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 13.6 Fold increase |
Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain
Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:10. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Days 0, 7, 14, 21, 28, 35 and 42
Population: The analysis was performed on the ATP cohort for immunogenicity, whiich included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Group | Value (GEOMETRIC_MEAN) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 48.1 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 38.0 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 5.1 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 54.3 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 22.1 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 56.0 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 46.6 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 79.3 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 25.3 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 57.6 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 66.1 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 5.0 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 116.3 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 119.9 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 42.2 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 49.1 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 5.0 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 27.7 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 56.0 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 65.8 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 63.7 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 71.5 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 128.0 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 37.6 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 141.4 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 160.0 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 5.0 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 77.1 Titers |
| Control Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 14 | 13.7 Titers |
| Control Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 443.0 Titers |
| Control Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 35 | 563.6 Titers |
| Control Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 28 | 543.9 Titers |
| Control Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 7 | 5.0 Titers |
| Control Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 5.0 Titers |
| Control Group | Titers for Serum H5N1 Haemaglutinin-inhibition (HI) Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 31.0 Titers |
Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain
Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:10. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Months 6, 12, 18 and 24
Population: The analysis was performed on the ATP cohort for persistence, which consisted of all subjects who had serologic results available at the antibody persistence time point.
| Arm | Measure | Group | Value (GEOMETRIC_MEAN) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 19.6 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 17.6 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 9.9 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 13.1 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 22.9 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 17.5 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 17.6 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 9.0 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 20.5 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 18.5 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 22.4 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 9.4 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 24.3 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 19.0 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 33.3 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 8.7 Titers |
| Control Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 10.9 Titers |
| Control Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 17.8 Titers |
| Control Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 16.2 Titers |
| Control Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 12.0 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 81.5 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 38.0 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 55.4 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 100.2 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 82.5 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 65.3 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 31.2 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 108.0 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 59.7 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 42.1 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 42.5 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 21.9 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 24 | 22.9 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 6 | 47.3 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 12 | 64.7 Titers |
| GSK1562902A AD Approved F Primed Group | Titers for Serum H5N1 HI Antibodies Against the A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Month 18 | 55.3 Titers |
Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain
Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:28. The flu strain assessed was A/Indonesia/05/2005.
Time frame: At Months 6, 12, 18 and 24
Population: The analysis was performed on the ATP cohort for persistence, which included all subjects who had serologic results available at the antibody persistence time-point.
| Arm | Measure | Group | Value (GEOMETRIC_MEAN) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 6 | 1422.2 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 12 | 557.6 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 18 | 767.5 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 24 | 503.2 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 24 | 201.6 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 6 | 502.3 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 18 | 278.5 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 12 | 180.7 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 24 | 295.4 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 12 | 274.4 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 18 | 569.9 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Stain | A/Indonesia/05/2005, Month 6 | 751.3 Titers |
Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain
Titers were presented as geometric mean titers (GMTs). The reference seropositivity cut-off value was equal to or above (≥) 1:28. The flu strain assessed was A/Indonesia/05/2005. No subject from GSK1562902A AD F1 Primed Group has received a second vaccination.
Time frame: At Days 0, 21 (post-vaccination one) and 42 (post-vaccination two)
Population: The analysis was performed on the ATP cohort for immunogenicity, which included all evaluable subjects for whom immunogenicity data and assay results for antibodies against at least one study vaccine antigen component after vaccination were available.
| Arm | Measure | Group | Value (GEOMETRIC_MEAN) |
|---|---|---|---|
| GSK1562902A AD F1 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 933.1 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 47.0 Titers |
| GSK1562902A AD F1 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 692.4 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 3708.9 Titers |
| GSK1562902A AD F2 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 157.8 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 42 | 1606.4 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 0 | 19.9 Titers |
| GSK1562902A AD F3 Primed Group | Titers for Serum Neutralizing HI Antibodies Against A/Indonesia/05/2005 Strain | A/Indonesia/05/2005, Day 21 | 307.3 Titers |