Knee Osteoarthritis
Conditions
Keywords
Derris Scandens Benth extract, Osteoarthritis, WOMAC, 6-minute walk
Brief summary
Derris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia. Previous study shown that D.Scandens Benth extract has the anti-inflammatory activity. Although NSAIDs are efficaciously in the treatment of osteoarthritis,but the GI side effect is still concerned. In this study we aim to investigate the efficacy and safety of D. Scandens Benth extract compared with Naproxen for therapy of patients with knee osteoarthritis.
Interventions
DRUGDerris scandens Benth extracts
Derris scandens Benth extracts (oral) 400 mg twice per day for 4 weeks
DRUGnaproxen
Naproxen 500 mg/day for 4 weeks
Sponsors
Ministry of Health, Thailand
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
50 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age \>=50 yr * Known case of primary knee osteoarthritis * WOMAC pain subscale (item1) \>= 5 * signed informed consent
Exclusion criteria
* hypersensitive to NSAIDs * history of peptic ulcer or melena * unable to walk , i.e. patient with severe spinal stenosis, myocardial infarction * history of intra-articular injection of knee within 3 months * status post knee replacement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC score | 2, 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| 6-minute walk, Quality of Life, adverse event | 2, 4 weeks |
Countries
Thailand
Outcome results
None listed