Bone Metastases
Conditions
Brief summary
Highly selective irradiation requires accurate target definition by high-resolution three-dimensional imaging. Co-registration of FDG-PET and high-resolution CT might be the imaging modality of choice. This choice might target radiation therapy precisely to the intra-osseous volume that is responsible for pain and to spare selectively healthy bone in the vicinity of the metastasis. This strategy could result in equal anti-pain efficacy as conventional large volume radiotherapy, but could allow bone remodeling and preservation of bone structural strength in the vicinity and could lead to reduced toxicity to neighboring organs.
Interventions
PROCEDUREBiological imaging guided antalgic radiotherapy
Biological imaging guided antalgic radiotherapy is followed.
Sponsors
University Hospital, Ghent
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Painful bone metastasis of solid tumors * A maximum number of bone metastases less or equal to 3 * Life expectancy \> 6 months * Minimum age 21 years * Signed informed consent
Exclusion criteria
* Previous radiotherapy to the painful site * Bone metastasis from malignant melanoma or renal cell carcinoma * Associated fracture or extra-osseous component
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain assessment | t0 |
Secondary
| Measure | Time frame |
|---|---|
| Acute toxicity | t0 |
| Bone remodeling | t0 |
| Resulting volumes of the targets and functional active areas | t0 |
| Mismatch and/or overlap areas | t0 |
Countries
Belgium
Outcome results
None listed