Diabetes Mellitus
Conditions
Keywords
phenylephrine, mydriasis, diabetes mellitus
Brief summary
To compare the clinical efficacy and systemic side effects between 2.5% and 10% phenylephrine for mydriasis in diabetic patient with darkly pigmented irides.
Detailed description
One hundred patients with diabetes from Srinagarind Hospital Eye Clinic were enrolled and randomized into two groups by block randomization. In group I (50 patients), 1% tropicamide combined with 2.5% phenylephrine were administered to dilate pupil whereas 1% tropicamide combined with 10% phenylephrine were used in Group II (50 patients). Pupil diameter, blood pressure and heart rate were measured before and after eye drop instillations.
Interventions
DRUG2.5% or 10% phenylephrine
Sponsors
Khon Kaen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* diabetic patients
Exclusion criteria
* history of intraocular surgery or laser treatment, * any ocular diseases that might affect pupil size such as glaucoma,uveitis,Horner's syndrome, Adies' pupil, * history of allergy to any drug used, and * hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pupil diameters were measured. | before and after phenylephrine eye drop instillations |
Secondary
| Measure | Time frame |
|---|---|
| blood pressure and heart rate were measured | before and after phenylephrine eye drop instillations |
Countries
Thailand
Outcome results
None listed