NAC in Preventing CIN in CRF Patients Who Need Enhanced CT Scan in ED

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00501475

Enrollment

Unknown

Registered

2007-07-16

Start date

2007-03-31

Completion date

2010-10-31

Last updated

2010-07-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Renal Failure

Keywords

N-acetylcysteine, nephropathy, bicarbonate

Brief summary

The purpose of this study is to evaluate the effect of NAC or sodium bicarbonate in preventing the aggravation of renal function in chronic renal failure when enhanced computed tomography scan is checked in emergency room.

Detailed description

CIN is frequent in CRF patients. However most studies about CIN has been focusing on elective PCI patients. There is no study that the NAC nor sodium bicarbonate would help in preventing CIN in CRF patients who need enhanced CT scan in ED. Our intention was to investigate the effect of NAC or sodium bicarbonate in preventing the aggravation of renal function in chronic renal failure when enhanced computed tomography scan is checked in emergency room.

Interventions

DRUGNAC Bicarbonate

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

15 Years to No maximum

Inclusion criteria

* CRF patients who need enhanced CT scan

Exclusion criteria

* less than 15 years old * hypersensitivity to NAC * on dialysis * no consent from patient or next of kin

Design outcomes

Primary

Measure	Time frame
the rate of CIN	3 days after CT scan

Secondary

Measure	Time frame
mortality	30 days after CT scan

Countries

South Korea

Contacts

Primary ContactKyuseok Kim, M.D

dremkks@snubh.org82-31-787-3049

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026