Fistula, Pancreas Cancer
Conditions
Keywords
Pancreas, Leakage, Fistula, tail
Brief summary
Randomized study assessing the effect of transpapillary pancreas duct stent in resection of the pancreatic tail.
Detailed description
Resection of the pancreatic tail is fraught with fistula or leakage of pancreatic enzymes to varying degrees between 13-64%, depending upon which definition one uses. The downstream control of the pancreatic duct with the help of a transpapillary stent might minimize the risk for leakage over the transected pancreas surface. Trial evaluation will be A. The pancreatic bed was drained and postoperatively the fluid was continuously collected and daily analysed for pancreatic amylase and bilirubin. Daily measurement of pancreatic enzyme content in the drain fluid, at least for 5 post operative days or as long as the patient retains the drain. X-Amylase and X-Protein as long as the patient has the external drain. B. Co-variables measured in the form of: operation time, complications in relation to diagnosis, duration of hospitalization. Patients receiving a pancreas stent are followed in order to evaluate the natural course of the pancreas stent.
Interventions
PROCEDUREstent
ERCP guided stent insertion before transection of the gland
PROCEDUREDistal pancreatectomy
conventional distal pancreatectomy
Sponsors
Karolinska Institutet
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Inclusion Criteria include all patients planned to undergo resection of the pancreatic body-tail are invited to participate.
Exclusion criteria
* The Patients who, at the time of exploration, judged to have a tumour, which is un-resectable.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Drain fluid content analyses | At least 5 postoperative days | Post-operative daily measurement of X-Amylase,as long as the patient has the external drain and for at least 5 postopertaive days. |
Secondary
| Measure | Time frame |
|---|---|
| Co-variables measured in the form of: operation time, complications in relation to diagnosis, duration of hospitalization and cost. Patients receiving a pancreas stent are followed in order to evaluate the natural course of the pancreas stent | At least 5 postoperative days |
Countries
Sweden
Outcome results
None listed