Quantitation of Left Ventricular Ejection Fraction as Part of F-18 FDG Whole Body PET/CT Scans For Tumor Staging

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00499382

Enrollment

Registered

2007-07-11

Start date

2004-09-30

Completion date

2009-03-31

Last updated

2012-08-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Advanced Cancers

Keywords

Advanced Cancers, Cardiac Function, Nuclear Medicine Cardiac Scan, Positron Emission Tomography, Radionuclide Ventriculography, Ventricular Ejection Fraction, PET/CT, RNV

Brief summary

Primary Objective: * Evaluate the agreement between radionuclide ventriculography (RNV) and gated F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in calculating left ventricular ejection fraction (LVEF), end diastolic volume (EDV) and end systolic volume (ESV).

Detailed description

Your doctor has ordered a PET/CT scan and a NM scan on you for routine care. By agreeing to take part in this study, you will go through both of these procedures as you normally would. For both imaging exams, you will be lying on your back. Every effort will be made to make you as comfortable as possible. For theNM cardiac scan, you will be hooked up to a heart monitor that will take a picture every time your heart beats. Your heart will be imaged from several different views. This exam will take about 30 minutes. The PET/CT cardiac scan will be done after completion of your normally scheduled PET/CT scan. For this scan, you will be hooked to a heart monitor that records the beats of your heart. While this monitor is attached, you will be imaged with the PET/CT scanner. The PET/CT cardiac scan will take about 10-15 minutes after your PET/CT exam is completed. Both imaging exams will provide a number that corresponds to the percent of blood pushed out of the left ventricle of your heart during a resting state. Taking part in this study should add between 10-15 additional minutes to your PET/CT visit. This is due to the additional cardiac imaging time. This is an investigational study. A total of up to 50 patients will take part in this study. All will be enrolled at UTMDACC.

Interventions

PROCEDUREPET/CT Cardiac Scan

Scan lasting 10-15 minutes and performed after the normally scheduled PET/CT scan.

PROCEDURENuclear Medicine Cardiac Scan

Scan lasting 30 minutes while being hooked up to a heart monitor that takes pictures every time your heart beats.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Patients undergoing both FDG PET/CT scan and RNV within two weeks interval, whether for initial staging, restaging or to evaluate response to therapy. * Patients who would consent to an additional 10-15 minutes acquisition of the gated images after completion of their FDG PET/CT study with the additional radiation exposure. * Patients with regular heart rate.

Exclusion criteria

* Blood glucose level above 200 mg/dL. * Irregular heart rate. * An interval of less than 1 day between the FDG PET/CT scan and RNV.

Design outcomes

Primary

Measure	Time frame
To compare the results, called an ejection fraction, of PET/CT and NM cardiac scans of heart.	5 Years

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026