Altitude, Environmental Sleep Disorder, Hypoxia
Conditions
Keywords
high altitude, sleep, altitude illness, neurobehavioral manifestations, psychomotor performance, mood states
Brief summary
Hypobaric hypoxia (decreased oxygen supply to body tissues due to low atmospheric pressure) caused by exposure to high altitude disrupts sleep. Sleep deprivation is associated with degraded post-sleep performance of neurobehavioral tasks. The lowest altitude at which sleep and/or post-sleep performance are affected is not known. The study hypothesis is that sleep and/or post-sleep performance of neurobehavioral tasks will occur due to hypobaric hypoxia at altitudes of 8,000 or less.
Interventions
PROCEDUREaltitude exposure in hypobaric chamber
Sponsors
The Boeing Company
Oklahoma State University Center for Health Sciences
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE
Eligibility
Sex/Gender
MALE
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy * age 30 to 60 years
Exclusion criteria
* sleep disorders or abnormal sleep patterns * mood or psychiatric disorders including claustrophobia * altitude exposure above 5,000 ft in the previous 2 months * born or raised at terrestrial altitude 5,000 ft or greater * conditions that would disqualify for FAA Medical Certificate * acute medical conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality and quantity of sleep measured by actigraphy and polysomnography Neurobehavioral performance measured by Psychomotor Vigilance Test (PVT) and Automated Neurophysiologic Assessment Metrics Battery (ANAM) | 7 hours; 4 hours |
Secondary
| Measure | Time frame |
|---|---|
| Mood State measured by Profile of Mood States (POMS) Symptoms of altitude illness measured by Environmental Symptoms Questionnaire (ESQ IV) and Lake Louise Symptom Scores (LLS) | 20 hours |
Countries
United States
Outcome results
None listed