An Observational Study of the Ethnic Impact of Patients Undergoing Second (2nd) Line Treatment for Non-Small Cell Lung Cancer Using Pemetrexed

Non-small Cell Lung Cancer: The Impact of Ethnic Origin on Patients Being Treated Second Line With Pemetrexed - An Observational Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00497770

Enrollment

434

Registered

2007-07-09

Start date

2007-02-28

Completion date

2011-03-31

Last updated

2012-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Neoplasms

Brief summary

This large, non-randomized observational study is being conducted to provide data about the impact of ethnic origin on outcomes and resource utilization during the 2nd line treatment of non-small cell lung cancer (NSCLC) in a routine medical care setting.

Detailed description

This is a large 1000 patient single arm observational study being conducted to determine the impact of ethnic origin (Caucasian, African-Americans, Asian-Americans, and Hispanics) on patients being treated for 2nd line advanced NSCLC with pemetrexed given in routine clinical practice. Data will be collected on disease control rate by pemetrexed as defined by Response Rate (RR) (Complete Response (CR) + Partial Response (PR)), Stable Disease (SD) and toxicities. In addition, overall survival, progression-free survival, treatment toxicities, activities of daily living, symptom burden and resource utilization will also be observed. To meet the study goals, a total of 400 Caucasians, 200 African- Americans, 200 Asian-Americans, and 200 Hispanics will be accrued to this study.

Interventions

DRUGPemetrexed

Treatment pattern and treatment initiation or changes are solely at the discretion of the physician and the patient

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Non-small cell lung cancer (NSCLC) (any histologic type) * Stage IIIB or IV disease * Should have had 1 line of chemotherapy for Metastatic disease * Adequate hematologic, hepatic and renal function * Measurable or evaluable disease

Exclusion criteria

* Pregnant or lactating females

Design outcomes

Primary

Measure	Time frame	Description
Percentage of Participants With a Best Overall Disease Control Response (Disease Control Rate)	baseline to measured progressive disease (up to 20 cycles [14 months])	Disease Control Rate \[DCR\] is the percentage of participants with Complete Response (CR), Partial Response (PR), Stable Disease (SD), and SD or Incomplete Response (SI). Response using Response Evaluation Criteria In Solid Tumors (RECIST) criteria. CR=disappearance of all target lesions; PR=30% decrease in sum of longest diameter of target lesions; Progressive Disease (PD)=20% increase in sum of longest diameter of target lesions; SD=small changes not meeting above criteria; SI=persistence of 1 or more non-target lesion(s) and/or maintenance of tumor marker level above normal limits.

Secondary

Measure	Time frame	Description
Progression Free Survival	baseline to measured progressive disease or death (up to 20 cycles [14 months])	Time from start of second line therapy until death, disease progression, or last contact expressed in months. Participants lost to follow-up (that were alive at last contact) were treated as censored using Kaplan-Meier survival analysis method.
Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])	The daily activities assessed: ability to plan and prepare meals. OARS-IADL assesses the participant's ability to plan and prepare meals at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.
Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])	The daily activities assessed: ability to drive or use public transportation. OARS-IADL assesses the participant's ability to drive or use public transportation at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.
Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])	The daily activities assessed: ability to handle personal finances. OARS-IADL assesses the participant's ability to handle personal finances at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.
Overall Survival	baseline to date of death from any cause (up to 20 cycles [14 months])	Overall survival is the duration (months) from enrollment to death. For patients who are alive, overall survival is censored at the last contact.
Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])	The daily activities assessed: ability to prepare and take medications. OARS-IADL assesses the participant's ability to prepare and take medications at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.
Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])	The daily activities assessed: ability to do the act of shopping. OARS-IADL assesses the participant's ability to do the act of shopping at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.
Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])	The daily activities assessed: ability to operate the telephone. OARS-IADL assesses the participant's ability to operate the telephone at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.
Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Baseline and end of treatment (up to 20 cycles [14 months])	The symptom score assessed: pain, fatigue, nausea, sleep, distress, shortness of breath, memory, appetite, drowsy, dry mouth, sadness, vomiting, numbness, cough, constipation, general activity, mood, work, relationships with other people, walking, enjoyment. Scores for each item range from 0 to 10, where 0 equaled no symptoms and 10 equaled worst possible symptoms. Assessed at baseline and end of treatment.
Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])	The daily activities assessed: ability to perform housework activities. OARS-IADL assesses the participant's ability to perform housework activities at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.

Countries

Puerto Rico, United States

Participant flow

Recruitment details

Target goals for recruitment were not met due to slow enrollment.

Participants by arm

Arm	Count
Caucasian Caucasian participants receiving pemetrexed for second (2nd) line non-small cell lung cancer (NSCLC)	304
African American African American participants receiving pemetrexed for 2nd line NSCLC	65
Asian American Asian American participants receiving pemetrexed for 2nd line NSCLC	37
Hispanic Hispanic participants receiving pemetrexed for 2nd line NSCLC	28
Total	434

Baseline characteristics

Characteristic	Caucasian	African American	Asian American	Hispanic	Total
Age Continuous	65.64 years STANDARD_DEVIATION 9.94	62.74 years STANDARD_DEVIATION 8.93	65.05 years STANDARD_DEVIATION 11.31	63.14 years STANDARD_DEVIATION 13.29	64.99 years STANDARD_DEVIATION 10.19
Disease Stage IIIB	60 participants	14 participants	8 participants	8 participants	90 participants
Disease Stage IV	244 participants	51 participants	29 participants	20 participants	344 participants
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 - Fully Active	58 participants	15 participants	12 participants	8 participants	93 participants
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 1 - Ambulatory, Restricted Strenuous Activity	166 participants	39 participants	15 participants	14 participants	234 participants
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 2 - Ambulatory, No Work Activities	53 participants	7 participants	3 participants	2 participants	65 participants
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 3 - Partially Confined to Bed, Limited Self Care	8 participants	1 participants	1 participants	1 participants	11 participants
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) Not available	19 participants	3 participants	6 participants	3 participants	31 participants
Histology of tumor Adenocarcinoma	191 participants	44 participants	33 participants	25 participants	293 participants
Histology of tumor Other [not adenocarcinoma or squamous cell]	36 participants	8 participants	2 participants	1 participants	47 participants
Histology of tumor Squamous Cell	77 participants	13 participants	2 participants	2 participants	94 participants
Region of Enrollment United States	304 participants	65 participants	37 participants	28 participants	434 participants
Sex: Female, Male Female	143 Participants	22 Participants	20 Participants	14 Participants	199 Participants
Sex: Female, Male Male	161 Participants	43 Participants	17 Participants	14 Participants	235 Participants
Smoking Status Current	83 participants	21 participants	0 participants	3 participants	107 participants
Smoking Status Former	196 participants	42 participants	13 participants	18 participants	269 participants
Smoking Status Never	21 participants	2 participants	24 participants	7 participants	54 participants
Smoking Status Not Collected	1 participants	0 participants	0 participants	0 participants	1 participants
Smoking Status Unknown	3 participants	0 participants	0 participants	0 participants	3 participants

Adverse events

Event type	EG000 affected / at risk	EG001 affected / at risk	EG002 affected / at risk	EG003 affected / at risk
deaths Total, all-cause mortality	— / —	— / —	— / —	— / —
other Total, other adverse events	256 / 304	54 / 65	27 / 37	21 / 28
serious Total, serious adverse events	21 / 304	4 / 65	1 / 37	1 / 28

Outcome results

Primary

Percentage of Participants With a Best Overall Disease Control Response (Disease Control Rate)

Disease Control Rate \[DCR\] is the percentage of participants with Complete Response (CR), Partial Response (PR), Stable Disease (SD), and SD or Incomplete Response (SI). Response using Response Evaluation Criteria In Solid Tumors (RECIST) criteria. CR=disappearance of all target lesions; PR=30% decrease in sum of longest diameter of target lesions; Progressive Disease (PD)=20% increase in sum of longest diameter of target lesions; SD=small changes not meeting above criteria; SI=persistence of 1 or more non-target lesion(s) and/or maintenance of tumor marker level above normal limits.

Time frame: baseline to measured progressive disease (up to 20 cycles [14 months])

Population: Of the 434 participants enrolled, 50 participants had a response status at the end of pemetrexed treatment indicating Not done/Missing and were not included in this analysis.

Arm	Measure	Value (NUMBER)
Caucasian	Percentage of Participants With a Best Overall Disease Control Response (Disease Control Rate)	43.7 percentage of participants
African American	Percentage of Participants With a Best Overall Disease Control Response (Disease Control Rate)	45.0 percentage of participants
Asian American	Percentage of Participants With a Best Overall Disease Control Response (Disease Control Rate)	53.33 percentage of participants
Hispanic	Percentage of Participants With a Best Overall Disease Control Response (Disease Control Rate)	34.6 percentage of participants

95% CI: [0.427, 1.58]Regression, Logistic

Secondary

Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals

The daily activities assessed: ability to plan and prepare meals. OARS-IADL assesses the participant's ability to plan and prepare meals at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.

Time frame: beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Group	Value (NUMBER)
Caucasian	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Without Help-baseline	63.2 percentage of participants
Caucasian	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Some Help-baseline	24.3 percentage of participants
Caucasian	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Unable-baseline	4.9 percentage of participants
Caucasian	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Not Done (missing)-baseline	7.6 percentage of participants
Caucasian	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Without Help-end of treatment	25.3 percentage of participants
Caucasian	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Some Help-end of treatment	9.5 percentage of participants
Caucasian	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Unable-end of treatment	4.3 percentage of participants
Caucasian	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Not Done (missing)-end of treatment	60.9 percentage of participants
African American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Some Help-end of treatment	13.8 percentage of participants
African American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Without Help-end of treatment	26.2 percentage of participants
African American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Some Help-baseline	23.1 percentage of participants
African American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Not Done (missing)-end of treatment	50.8 percentage of participants
African American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Unable-end of treatment	9.2 percentage of participants
African American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Not Done (missing)-baseline	4.6 percentage of participants
African American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Unable-baseline	9.2 percentage of participants
African American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Without Help-baseline	63.1 percentage of participants
Asian American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Unable-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Unable-baseline	10.8 percentage of participants
Asian American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Not Done (missing)-baseline	5.4 percentage of participants
Asian American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Without Help-end of treatment	37.8 percentage of participants
Asian American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Some Help-end of treatment	8.1 percentage of participants
Asian American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Not Done (missing)-end of treatment	54.1 percentage of participants
Asian American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Without Help-baseline	70.3 percentage of participants
Asian American	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Some Help-baseline	13.5 percentage of participants
Hispanic	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Unable-baseline	17.9 percentage of participants
Hispanic	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Not Done (missing)-baseline	0.0 percentage of participants
Hispanic	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Some Help-baseline	10.7 percentage of participants
Hispanic	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Without Help-baseline	71.4 percentage of participants
Hispanic	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Without Help-end of treatment	14.3 percentage of participants
Hispanic	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Not Done (missing)-end of treatment	71.4 percentage of participants
Hispanic	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Unable-end of treatment	3.6 percentage of participants
Hispanic	Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals	Some Help-end of treatment	10.7 percentage of participants

Secondary

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping

The daily activities assessed: ability to do the act of shopping. OARS-IADL assesses the participant's ability to do the act of shopping at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.

Time frame: beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Group	Value (NUMBER)
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Without Help-baseline	57.2 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Some Help-baseline	29.9 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Unable-baseline	5.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Not Done (missing)-baseline	7.2 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Without Help-end of treatment	20.1 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Some Help-end of treatment	14.1 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Unable-end of treatment	4.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Not Done (missing)-end of treatment	61.2 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Some Help-end of treatment	21.5 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Without Help-end of treatment	24.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Some Help-baseline	32.3 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Not Done (missing)-end of treatment	50.8 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Unable-end of treatment	3.1 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Not Done (missing)-baseline	4.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Unable-baseline	4.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Without Help-baseline	58.5 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Unable-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Unable-baseline	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Not Done (missing)-baseline	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Without Help-end of treatment	40.5 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Some Help-end of treatment	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Not Done (missing)-end of treatment	54.1 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Without Help-baseline	59.5 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Some Help-baseline	29.7 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Unable-baseline	14.3 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Not Done (missing)-baseline	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Some Help-baseline	35.7 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Without Help-baseline	50.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Without Help-end of treatment	14.3 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Not Done (missing)-end of treatment	71.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Unable-end of treatment	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping	Some Help-end of treatment	14.3 percentage of participants

Secondary

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation

The daily activities assessed: ability to drive or use public transportation. OARS-IADL assesses the participant's ability to drive or use public transportation at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.

Time frame: beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Group	Value (NUMBER)
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Without Help-baseline	62.2 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Some Help-baseline	29.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Unable-baseline	0.7 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Not Done (missing)-baseline	7.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Without Help-end of treatment	23.4 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Some Help-end of treatment	14.8 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Unable-end of treatment	1.0 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Not Done (missing)-end of treatment	60.9 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Some Help-end of treatment	20.0 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Without Help-end of treatment	29.2 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Some Help-baseline	32.3 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Not Done (missing)-end of treatment	50.8 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Unable-end of treatment	0.0 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Not Done (missing)-baseline	4.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Unable-baseline	0.0 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Without Help-baseline	63.1 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Unable-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Unable-baseline	2.7 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Not Done (missing)-baseline	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Without Help-end of treatment	45.9 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Some Help-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Not Done (missing)-end of treatment	54.1 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Without Help-baseline	62.2 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Some Help-baseline	29.7 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Unable-baseline	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Not Done (missing)-baseline	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Some Help-baseline	50.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Without Help-baseline	50.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Without Help-end of treatment	21.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Not Done (missing)-end of treatment	71.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Unable-end of treatment	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation	Some Help-end of treatment	7.1 percentage of participants

Secondary

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances

The daily activities assessed: ability to handle personal finances. OARS-IADL assesses the participant's ability to handle personal finances at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.

Time frame: beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Group	Value (NUMBER)
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Without Help-baseline	78.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Some Help-baseline	11.5 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Unable-baseline	2.3 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Not Done (missing)-baseline	7.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Without Help-end of treatment	31.9 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Some Help-end of treatment	5.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Unable-end of treatment	1.3 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Not Done (missing)-end of treatment	61.2 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Some Help-end of treatment	10.8 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Without Help-end of treatment	38.5 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Some Help-baseline	26.2 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Not Done (missing)-end of treatment	50.8 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Unable-end of treatment	0.0 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Not Done (missing)-baseline	6.2 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Unable-baseline	0.0 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Without Help-baseline	67.7 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Unable-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Unable-baseline	2.7 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Not Done (missing)-baseline	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Without Help-end of treatment	45.9 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Some Help-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Not Done (missing)-end of treatment	54.1 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Without Help-baseline	83.8 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Some Help-baseline	8.1 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Unable-baseline	10.7 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Not Done (missing)-baseline	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Some Help-baseline	17.9 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Without Help-baseline	71.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Without Help-end of treatment	25.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Not Done (missing)-end of treatment	71.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Unable-end of treatment	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances	Some Help-end of treatment	3.6 percentage of participants

Secondary

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone

The daily activities assessed: ability to operate the telephone. OARS-IADL assesses the participant's ability to operate the telephone at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.

Time frame: beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Group	Value (NUMBER)
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Without Help-baseline	86.5 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Some Help-baseline	5.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Unable-baseline	0.0 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Not Done (missing)-baseline	7.9 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Without Help-end of treatment	34.9 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Some Help-end of treatment	3.0 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Unable-end of treatment	1.3 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Not Done (missing)-end of treatment	60.9 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Some Help-end of treatment	7.7 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Without Help-end of treatment	41.5 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Some Help-baseline	4.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Not Done (missing)-end of treatment	50.8 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Unable-end of treatment	0.0 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Not Done (missing)-baseline	4.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Unable-baseline	0.0 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Without Help-baseline	90.8 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Unable-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Unable-baseline	2.7 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Not Done (missing)-baseline	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Without Help-end of treatment	45.9 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Some Help-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Not Done (missing)-end of treatment	54.1 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Without Help-baseline	86.5 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Some Help-baseline	5.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Unable-baseline	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Not Done (missing)-baseline	3.6 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Some Help-baseline	3.6 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Without Help-baseline	92.9 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Without Help-end of treatment	25.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Not Done (missing)-end of treatment	71.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Unable-end of treatment	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone	Some Help-end of treatment	3.6 percentage of participants

Secondary

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities

The daily activities assessed: ability to perform housework activities. OARS-IADL assesses the participant's ability to perform housework activities at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.

Time frame: beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Group	Value (NUMBER)
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Without Help-baseline	44.1 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Some Help-baseline	38.2 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Unable-baseline	9.5 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Not Done (missing)-baseline	8.2 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Without Help-end of treatment	15.8 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Some Help-end of treatment	15.5 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Unable-end of treatment	7.2 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Not Done (missing)-end of treatment	61.5 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Some Help-end of treatment	18.5 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Without Help-end of treatment	21.5 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Some Help-baseline	33.8 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Not Done (missing)-end of treatment	50.8 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Unable-end of treatment	9.2 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Not Done (missing)-baseline	4.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Unable-baseline	16.9 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Without Help-baseline	44.6 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Unable-end of treatment	2.7 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Unable-baseline	8.1 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Not Done (missing)-baseline	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Without Help-end of treatment	27.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Some Help-end of treatment	16.2 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Not Done (missing)-end of treatment	54.1 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Without Help-baseline	54.1 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Some Help-baseline	32.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Unable-baseline	25.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Not Done (missing)-baseline	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Some Help-baseline	32.1 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Without Help-baseline	42.9 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Without Help-end of treatment	10.7 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Not Done (missing)-end of treatment	71.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Unable-end of treatment	3.6 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities	Some Help-end of treatment	14.3 percentage of participants

Secondary

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications

The daily activities assessed: ability to prepare and take medications. OARS-IADL assesses the participant's ability to prepare and take medications at baseline and end of treatment. Responses: ability to do the activity without help, some help, unable, or not done (missing). The percent of participants responding in the different levels of functional ability are provided.

Time frame: beginning and at end of pemetrexed treatment (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Group	Value (NUMBER)
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Without Help-baseline	79.3 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Some Help-baseline	12.8 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Unable-baseline	0.7 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Not Done (missing)-baseline	7.2 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Without Help-end of treatment	30.9 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Some Help-end of treatment	7.6 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Unable-end of treatment	0.7 percentage of participants
Caucasian	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Not Done (missing)-end of treatment	7.2 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Some Help-end of treatment	10.8 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Without Help-end of treatment	36.9 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Some Help-baseline	21.5 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Not Done (missing)-end of treatment	4.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Unable-end of treatment	1.5 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Not Done (missing)-baseline	4.6 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Unable-baseline	0.0 percentage of participants
African American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Without Help-baseline	73.8 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Unable-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Unable-baseline	2.7 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Not Done (missing)-baseline	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Without Help-end of treatment	45.9 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Some Help-end of treatment	0.0 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Not Done (missing)-end of treatment	5.4 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Without Help-baseline	86.5 percentage of participants
Asian American	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Some Help-baseline	5.4 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Unable-baseline	7.1 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Not Done (missing)-baseline	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Some Help-baseline	7.1 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Without Help-baseline	85.7 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Without Help-end of treatment	25.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Not Done (missing)-end of treatment	0.0 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Unable-end of treatment	3.6 percentage of participants
Hispanic	Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications	Some Help-end of treatment	0.0 percentage of participants

Secondary

Overall Survival

Overall survival is the duration (months) from enrollment to death. For patients who are alive, overall survival is censored at the last contact.

Time frame: baseline to date of death from any cause (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Value (MEDIAN)	Dispersion
Caucasian	Overall Survival	6.77 months	95% Confidence Interval 0.38
African American	Overall Survival	6.90 months	95% Confidence Interval 1.34
Asian American	Overall Survival	16.0 months	95% Confidence Interval 1.06
Hispanic	Overall Survival	5.35 months	95% Confidence Interval 0.91

Secondary

Progression Free Survival

Time from start of second line therapy until death, disease progression, or last contact expressed in months. Participants lost to follow-up (that were alive at last contact) were treated as censored using Kaplan-Meier survival analysis method.

Time frame: baseline to measured progressive disease or death (up to 20 cycles [14 months])

Population: All participants enrolled in the study.

Arm	Measure	Value (MEDIAN)
Caucasian	Progression Free Survival	2.66 months
African American	Progression Free Survival	2.99 months
Asian American	Progression Free Survival	5.08 months
Hispanic	Progression Free Survival	2.20 months

Secondary

Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)

The symptom score assessed: pain, fatigue, nausea, sleep, distress, shortness of breath, memory, appetite, drowsy, dry mouth, sadness, vomiting, numbness, cough, constipation, general activity, mood, work, relationships with other people, walking, enjoyment. Scores for each item range from 0 to 10, where 0 equaled no symptoms and 10 equaled worst possible symptoms. Assessed at baseline and end of treatment.

Time frame: Baseline and end of treatment (up to 20 cycles [14 months])

Population: The number of participants who had measurements for the subscale at those time points.

Arm	Measure	Group	Value (MEAN)	Dispersion
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sadness-EOT (n=119, 32, 17, 8)	2.39 participants	Standard Deviation 2.83
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sadness-baseline (n=278, 61, 35, 28)	2.40 participants	Standard Deviation 2.81
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Shortness of Breath-EOT (n=118, 32, 17, 8)	3.76 participants	Standard Deviation 3.12
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Relationships with Others-baseline(n=282,61,35,28)	1.83 participants	Standard Deviation 2.53
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Dry Mouth-EOT (n=119, 32, 17, 8)	2.91 participants	Standard Deviation 2.99
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Dry Mouth-baseline (n=279, 62, 35, 28)	2.89 participants	Standard Deviation 2.98
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Memory-baseline (n=278, 62, 35, 28)	2.40 participants	Standard Deviation 2.56
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Fatigue-EOT (n=119, 32, 17, 8)	4.98 participants	Standard Deviation 2.72
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Drowsy-EOT (n=119, 32, 17, 8)	3.30 participants	Standard Deviation 2.84
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Drowsy-baseline (n=280, 65, 32, 28)	3.20 participants	Standard Deviation 2.79
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Memory-EOT (n=119, 32, 17, 8)	2.47 participants	Standard Deviation 2.56
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Pain-end of treatment (EOT) (n=118, 31, 17, 8)	3.52 participants	Standard Deviation 3.25
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Appetite-EOT (n=119, 32, 16, 8)	2.87 participants	Standard Deviation 3.01
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Appetite-baseline (n=281, 62, 35, 28)	2.84 participants	Standard Deviation 3.02
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Work-EOT (n=118, 32, 16, 8)	4.05 participants	Standard Deviation 3.47
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Work-baseline (n=278, 62, 35, 28)	3.72 participants	Standard Deviation 3.32
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Nausea-baseline (n=280, 62, 35, 28)	1.39 participants	Standard Deviation 2.54
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Enjoyment-EOT (n=119, 32, 16, 8)	3.39 participants	Standard Deviation 3.16
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Mood-EOT (n=119, 32, 16, 8)	2.07 participants	Standard Deviation 2.24
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Mood-baseline (n=279, 61, 34, 28)	2.85 participants	Standard Deviation 2.96
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Nausea-EOT (n=118, 30, 17, 8)	1.76 participants	Standard Deviation 2.67
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Pain-baseline (n=281, 62, 35, 28)	3.37 participants	Standard Deviation 3.27
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	General Activity-EOT (n=119,32,16,8)	3.89 participants	Standard Deviation 3.04
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	General Activity-baseline (n=280, 62, 35, 28)	3.71 participants	Standard Deviation 3.13
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sleep-baseline (n=280, 62, 34, 28)	3.24 participants	Standard Deviation 3.07
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Walking-EOT (n=119, 32, 16, 8)	4.12 participants	Standard Deviation 3.32
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Constipation-EOT (n=119, 32 17, 8)	2.55 participants	Standard Deviation 2.85
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Constipation-baseline (n=281, 62 34, 28)	2.47 participants	Standard Deviation 3.11
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sleep-EOT (n=118, 31, 17, 8)	3.58 participants	Standard Deviation 2.97
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Walking-baseline (n=280, 62, 35, 28)	3.84 participants	Standard Deviation 3.15
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Cough-EOT (n=119, 31, 16, 8)	2.50 participants	Standard Deviation 2.63
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Cough-baseline (n=281, 61, 35, 28)	2.89 participants	Standard Deviation 2.92
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Distress (Upset)-baseline (n=277, 62, 34, 28)	2.89 participants	Standard Deviation 3.01
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Fatigue-baseline (n=279, 62, 35, 28)	4.63 participants	Standard Deviation 2.83
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Numbness-EOT (n=119, 32, 17, 8)	2.34 participants	Standard Deviation 2.64
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Numbness-baseline (n=280, 61, 33, 28)	2.42 participants	Standard Deviation 2.99
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Distress (Upset)-EOT (n=119, 32, 17, 8)	3.05 participants	Standard Deviation 2.94
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Enjoyment-baseline (n=282, 61, 35, 28)	3.33 participants	Standard Deviation 3.26
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Vomiting-EOT (n=119, 32, 17, 8)	0.97 participants	Standard Deviation 1.49
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Vomiting-baseline (n=282, 62, 35, 28)	0.74 participants	Standard Deviation 1.85
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Shortness of Breath-baseline (n=282, 61, 35, 28)	3.58 participants	Standard Deviation 3.06
Caucasian	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Relationships with Others-EOT (n=118, 31, 16, 8)	2.17 participants	Standard Deviation 2.76
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Nausea-EOT (n=118, 30, 17, 8)	1.67 participants	Standard Deviation 2.66
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Pain-baseline (n=281, 62, 35, 28)	3.73 participants	Standard Deviation 3.63
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Pain-end of treatment (EOT) (n=118, 31, 17, 8)	5.16 participants	Standard Deviation 3.69
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Fatigue-baseline (n=279, 62, 35, 28)	4.58 participants	Standard Deviation 3.11
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Fatigue-EOT (n=119, 32, 17, 8)	4.91 participants	Standard Deviation 3.3
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Nausea-baseline (n=280, 62, 35, 28)	1.55 participants	Standard Deviation 2.6
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sleep-baseline (n=280, 62, 34, 28)	3.66 participants	Standard Deviation 3.59
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sleep-EOT (n=118, 31, 17, 8)	4.16 participants	Standard Deviation 3.4
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Distress (Upset)-baseline (n=277, 62, 34, 28)	3.00 participants	Standard Deviation 3.23
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Distress (Upset)-EOT (n=119, 32, 17, 8)	3.22 participants	Standard Deviation 3.58
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Shortness of Breath-baseline (n=282, 61, 35, 28)	3.70 participants	Standard Deviation 3.12
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Shortness of Breath-EOT (n=118, 32, 17, 8)	5.06 participants	Standard Deviation 3.32
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Memory-baseline (n=278, 62, 35, 28)	2.71 participants	Standard Deviation 2.56
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Memory-EOT (n=119, 32, 17, 8)	2.81 participants	Standard Deviation 3.06
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Appetite-baseline (n=281, 62, 35, 28)	3.11 participants	Standard Deviation 3.38
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Appetite-EOT (n=119, 32, 16, 8)	4.72 participants	Standard Deviation 4.03
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Drowsy-baseline (n=280, 65, 32, 28)	3.32 participants	Standard Deviation 2.97
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Drowsy-EOT (n=119, 32, 17, 8)	3.69 participants	Standard Deviation 3.56
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Dry Mouth-baseline (n=279, 62, 35, 28)	2.73 participants	Standard Deviation 3.06
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Dry Mouth-EOT (n=119, 32, 17, 8)	2.44 participants	Standard Deviation 3.04
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sadness-baseline (n=278, 61, 35, 28)	2.57 participants	Standard Deviation 3.23
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sadness-EOT (n=119, 32, 17, 8)	2.81 participants	Standard Deviation 3.59
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Vomiting-baseline (n=282, 62, 35, 28)	0.97 participants	Standard Deviation 2.06
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Vomiting-EOT (n=119, 32, 17, 8)	1.06 participants	Standard Deviation 2.03
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Numbness-baseline (n=280, 61, 33, 28)	3.34 participants	Standard Deviation 3.26
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Numbness-EOT (n=119, 32, 17, 8)	3.84 participants	Standard Deviation 3.47
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Cough-baseline (n=281, 61, 35, 28)	2.98 participants	Standard Deviation 2.91
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Cough-EOT (n=119, 31, 16, 8)	3.94 participants	Standard Deviation 3.21
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Constipation-baseline (n=281, 62 34, 28)	2.37 participants	Standard Deviation 3.17
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Constipation-EOT (n=119, 32 17, 8)	2.88 participants	Standard Deviation 3.5
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	General Activity-baseline (n=280, 62, 35, 28)	3.56 participants	Standard Deviation 3.38
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	General Activity-EOT (n=119,32,16,8)	4.53 participants	Standard Deviation 3.65
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Mood-baseline (n=279, 61, 34, 28)	3.11 participants	Standard Deviation 3.07
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Mood-EOT (n=119, 32, 16, 8)	1.88 participants	Standard Deviation 2.23
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Work-baseline (n=278, 62, 35, 28)	4.23 participants	Standard Deviation 3.86
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Work-EOT (n=118, 32, 16, 8)	4.63 participants	Standard Deviation 3.72
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Relationships with Others-baseline(n=282,61,35,28)	2.41 participants	Standard Deviation 3.07
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Relationships with Others-EOT (n=118, 31, 16, 8)	2.71 participants	Standard Deviation 3.13
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Walking-baseline (n=280, 62, 35, 28)	4.00 participants	Standard Deviation 3.39
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Walking-EOT (n=119, 32, 16, 8)	4.44 participants	Standard Deviation 3.56
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Enjoyment-baseline (n=282, 61, 35, 28)	3.51 participants	Standard Deviation 3.38
African American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Enjoyment-EOT (n=119, 32, 16, 8)	4.00 participants	Standard Deviation 3.77
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Shortness of Breath-baseline (n=282, 61, 35, 28)	2.69 participants	Standard Deviation 3
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sadness-EOT (n=119, 32, 17, 8)	2.06 participants	Standard Deviation 2.08
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Fatigue-baseline (n=279, 62, 35, 28)	4.14 participants	Standard Deviation 2.37
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Vomiting-baseline (n=282, 62, 35, 28)	0.66 participants	Standard Deviation 1.35
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Distress (Upset)-EOT (n=119, 32, 17, 8)	2.41 participants	Standard Deviation 1.97
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Vomiting-EOT (n=119, 32, 17, 8)	0.88 participants	Standard Deviation 2.03
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Relationships with Others-EOT (n=118, 31, 16, 8)	1.50 participants	Standard Deviation 2.31
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Numbness-baseline (n=280, 61, 33, 28)	2.76 participants	Standard Deviation 2.72
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Distress (Upset)-baseline (n=277, 62, 34, 28)	2.76 participants	Standard Deviation 2.71
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Numbness-EOT (n=119, 32, 17, 8)	2.47 participants	Standard Deviation 2.15
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Cough-baseline (n=281, 61, 35, 28)	2.63 participants	Standard Deviation 2.77
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sleep-EOT (n=118, 31, 17, 8)	2.94 participants	Standard Deviation 3.27
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Pain-baseline (n=281, 62, 35, 28)	3.89 participants	Standard Deviation 3.32
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Cough-EOT (n=119, 31, 16, 8)	1.63 participants	Standard Deviation 1.96
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Walking-baseline (n=280, 62, 35, 28)	2.80 participants	Standard Deviation 2.75
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Constipation-baseline (n=281, 62 34, 28)	2.79 participants	Standard Deviation 3.22
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sleep-baseline (n=280, 62, 34, 28)	3.21 participants	Standard Deviation 3.27
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Constipation-EOT (n=119, 32 17, 8)	2.47 participants	Standard Deviation 3.1
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Pain-end of treatment (EOT) (n=118, 31, 17, 8)	1.82 participants	Standard Deviation 2.3
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	General Activity-baseline (n=280, 62, 35, 28)	2.46 participants	Standard Deviation 2.69
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Nausea-EOT (n=118, 30, 17, 8)	1.18 participants	Standard Deviation 1.33
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	General Activity-EOT (n=119,32,16,8)	2.88 participants	Standard Deviation 2.7
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Walking-EOT (n=119, 32, 16, 8)	2.94 participants	Standard Deviation 2.54
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Mood-baseline (n=279, 61, 34, 28)	2.44 participants	Standard Deviation 2.78
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Nausea-baseline (n=280, 62, 35, 28)	1.34 participants	Standard Deviation 2.18
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Mood-EOT (n=119, 32, 16, 8)	1.89 participants	Standard Deviation 2.26
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Work-baseline (n=278, 62, 35, 28)	2.51 participants	Standard Deviation 2.45
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Fatigue-EOT (n=119, 32, 17, 8)	3.71 participants	Standard Deviation 2.76
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Appetite-baseline (n=281, 62, 35, 28)	3.37 participants	Standard Deviation 2.73
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Memory-EOT (n=119, 32, 17, 8)	1.82 participants	Standard Deviation 2.38
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Enjoyment-EOT (n=119, 32, 16, 8)	2.81 participants	Standard Deviation 2.54
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Appetite-EOT (n=119, 32, 16, 8)	2.38 participants	Standard Deviation 2.58
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Work-EOT (n=118, 32, 16, 8)	2.81 participants	Standard Deviation 2.48
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Drowsy-baseline (n=280, 65, 32, 28)	2.63 participants	Standard Deviation 2.38
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Memory-baseline (n=278, 62, 35, 28)	2.09 participants	Standard Deviation 2.31
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Drowsy-EOT (n=119, 32, 17, 8)	1.59 participants	Standard Deviation 1.84
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Dry Mouth-baseline (n=279, 62, 35, 28)	3.29 participants	Standard Deviation 3.19
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Shortness of Breath-EOT (n=118, 32, 17, 8)	1.82 participants	Standard Deviation 2.53
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Enjoyment-baseline (n=282, 61, 35, 28)	2.83 participants	Standard Deviation 2.81
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Dry Mouth-EOT (n=119, 32, 17, 8)	2.71 participants	Standard Deviation 2.78
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Relationships with Others-baseline(n=282,61,35,28)	2.00 participants	Standard Deviation 2.52
Asian American	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sadness-baseline (n=278, 61, 35, 28)	2.74 participants	Standard Deviation 2.81
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Appetite-EOT (n=119, 32, 16, 8)	4.00 participants	Standard Deviation 3.74
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Relationships with Others-baseline(n=282,61,35,28)	3.07 participants	Standard Deviation 3.57
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	General Activity-EOT (n=119,32,16,8)	3.63 participants	Standard Deviation 3.5
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sadness-EOT (n=119, 32, 17, 8)	3.88 participants	Standard Deviation 3.72
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Distress (Upset)-EOT (n=119, 32, 17, 8)	3.63 participants	Standard Deviation 4.1
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Nausea-baseline (n=280, 62, 35, 28)	2.43 participants	Standard Deviation 3.49
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Memory-baseline (n=278, 62, 35, 28)	2.50 participants	Standard Deviation 2.77
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Vomiting-baseline (n=282, 62, 35, 28)	1.25 participants	Standard Deviation 2.59
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sadness-baseline (n=278, 61, 35, 28)	4.32 participants	Standard Deviation 3.51
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Enjoyment-baseline (n=282, 61, 35, 28)	4.39 participants	Standard Deviation 4.04
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Mood-baseline (n=279, 61, 34, 28)	3.86 participants	Standard Deviation 3.76
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Vomiting-EOT (n=119, 32, 17, 8)	0.13 participants	Standard Deviation 0.35
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Distress (Upset)-baseline (n=277, 62, 34, 28)	4.07 participants	Standard Deviation 3.57
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Dry Mouth-baseline (n=279, 62, 35, 28)	3.36 participants	Standard Deviation 3.41
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Walking-EOT (n=119, 32, 16, 8)	4.00 participants	Standard Deviation 3.82
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Numbness-baseline (n=280, 61, 33, 28)	2.39 participants	Standard Deviation 3.4
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Drowsy-baseline (n=280, 65, 32, 28)	4.36 participants	Standard Deviation 3.18
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Relationships with Others-EOT (n=118, 31, 16, 8)	2.75 participants	Standard Deviation 3.96
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Mood-EOT (n=119, 32, 16, 8)	1.86 participants	Standard Deviation 2.97
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Numbness-EOT (n=119, 32, 17, 8)	0.63 participants	Standard Deviation 1.77
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sleep-EOT (n=118, 31, 17, 8)	3.13 participants	Standard Deviation 3.8
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Pain-end of treatment (EOT) (n=118, 31, 17, 8)	1.88 participants	Standard Deviation 2.17
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Fatigue-EOT (n=119, 32, 17, 8)	4.00 participants	Standard Deviation 3.74
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Cough-baseline (n=281, 61, 35, 28)	2.61 participants	Standard Deviation 3.44
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Pain-baseline (n=281, 62, 35, 28)	3.75 participants	Standard Deviation 3.95
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Dry Mouth-EOT (n=119, 32, 17, 8)	2.25 participants	Standard Deviation 2.96
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Work-baseline (n=278, 62, 35, 28)	4.86 participants	Standard Deviation 3.95
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Cough-EOT (n=119, 31, 16, 8)	3.13 participants	Standard Deviation 3.6
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Sleep-baseline (n=280, 62, 34, 28)	4.11 participants	Standard Deviation 2.97
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Memory-EOT (n=119, 32, 17, 8)	0.63 participants	Standard Deviation 1.19
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Work-EOT (n=118, 32, 16, 8)	4.25 participants	Standard Deviation 3.77
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Constipation-baseline (n=281, 62 34, 28)	3.54 participants	Standard Deviation 3.86
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Shortness of Breath-baseline (n=282, 61, 35, 28)	4.29 participants	Standard Deviation 3.4
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Walking-baseline (n=280, 62, 35, 28)	4.21 participants	Standard Deviation 3.35
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Appetite-baseline (n=281, 62, 35, 28)	4.86 participants	Standard Deviation 3.3
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Constipation-EOT (n=119, 32 17, 8)	1.50 participants	Standard Deviation 1.77
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Nausea-EOT (n=118, 30, 17, 8)	0.75 participants	Standard Deviation 1.39
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Drowsy-EOT (n=119, 32, 17, 8)	3.13 participants	Standard Deviation 3.18
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Shortness of Breath-EOT (n=118, 32, 17, 8)	2.88 participants	Standard Deviation 3.44
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	General Activity-baseline (n=280, 62, 35, 28)	4.46 participants	Standard Deviation 3.89
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Fatigue-baseline (n=279, 62, 35, 28)	5.04 participants	Standard Deviation 3.28
Hispanic	Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)	Enjoyment-EOT (n=119, 32, 16, 8)	4.00 participants	Standard Deviation 4.75

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026

An Observational Study of the Ethnic Impact of Patients Undergoing Second (2nd) Line Treatment for Non-Small Cell Lung Cancer Using Pemetrexed

Conditions

Brief summary

Detailed description

Related papers

Interventions

Sponsors

Study design

Eligibility

Inclusion criteria

Exclusion criteria

Design outcomes

Primary

Secondary

Countries

Participant flow

Recruitment details

Participants by arm

Baseline characteristics

Adverse events

Outcome results

Percentage of Participants With a Best Overall Disease Control Response (Disease Control Rate)

Functional Status Based on Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Plan and Prepare Meals

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to do the Act of Shopping

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Drive or Use Public Transportation

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Handle Personal Finances

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Operate the Telephone

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Perform Housework Activities

Functional Status Based on the Older Americans Resources and Services Instrumental Activities of Daily Living Scale(OARS-IADL), Ability to Prepare and Take Medications

Overall Survival

Progression Free Survival

Symptom Score Associated With Treatment as Measured by the M.D. Anderson Symptom Inventory - LC(MDASI-LC)