A Pharmacokinetic Study of Cefepime After Administration Into Dialysate in Patients With Continuous Ambulatory Peritoneal Dialysis (CAPD) Peritonitis

Research Study on the Pharmacokinetic Profile of Intraperitoneal Cefepime in Patients With Continuous Ambulatory Peritoneal Dialysis (CAPD) Peritonitis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00497744

Enrollment

Registered

2007-07-09

Start date

2005-11-30

Completion date

2007-12-31

Last updated

2011-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peritonitis

Keywords

CAPD peritonitis, Peritoneal Dialysis, Continuous Ambulatory

Brief summary

Cefepime is a broad-spectrum antibiotic used in treating CAPD peritonitis. However, medical knowledge has been lacking with regard to its pharmacokinetic profile after it has been administered intraperitoneally. The current study aims at determining the drug level at different time after the drug has been added into the peritoneal fluid in patients with CAPD peritonitis. The results of this study will finally leads to rational prescription of this drug at correct dosages.

Interventions

DRUGIntraperitoneal Cefepime

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Age \>= 18 years & has been put on CAPD for \>= 4 weeks before entering into the study

Exclusion criteria

* Known hypersensitivity to cefepime or other cephalosporin; CAPD peritonitis \<= 28 days before being enrolled into the study * Antibiotic treatment within 1 week prior to entry into the study * Severe exit site or tunnel infection on the day of presentation * Any conditions that prompt early removal of Tenckhoff catheter irrespective of clinical response to antibiotic treatment * Abdominal malignancy; Any surgical causes of peritonitis * Suspected or known fungal or tuberculous peritonitis * History of dementia or known mental incompetency

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026