Sleep Apnea
Conditions
Keywords
sleep apnea, snoring, acetazolamide, uvulopalatopharyngoplasty, daytime sleepiness, upper airway
Brief summary
The aim of the study is to investigate wether the adjuvant (postoperative) administration of acetazolamide can improve the surgical results after uvulopalatopharyngoplasty in patients with mild sleep apnea.
Interventions
DRUGacetazolamide
DRUGplacebo
PROCEDUREuvulopalatopharygoplasty
Sponsors
University Hospital, Antwerp
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* 5 ≤ Apnea Hypopnea Index (AHI) \< 20 * Socially disturbing snoring: Visual Analogue Scale (VAS)snoring \> 6/10 * Based on clinical examination and polysomnography, patient is regarded eligible for uvulopalatopharyngoplasty (UPPP)
Exclusion criteria
* Previous surgical treatment for sleep-disordered breathing. * Periodic Limb Movement Disorder (PLMD) with arousals and other reasons possibly explaining the Excessive Daytime Sleepiness (EDS) based on Epworth Sleepiness Scale (ESS). * Forced expiratory volume in 1 second (FEV1) \< 80 % pred. * Echocardiography: ejectionfraction \< 35 % or dyastolic dysfunction grade 2 or more.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Polysomnographic parameters | — |
Secondary
| Measure | Time frame |
|---|---|
| subjective sleepiness | — |
| subjective snoring | — |
| satisfaction | — |
Countries
Belgium
Contacts
Primary ContactWilfried De Backer, MD PhD
Outcome results
None listed