Does Statin Therapy Reduce Sympathoexcitation in Hypertension?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00497016

Enrollment

Registered

2007-07-06

Start date

2007-05-31

Completion date

2008-03-31

Last updated

2008-09-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Keywords

hypertension, statin, sympathetic

Brief summary

A number of patients with hypertension have increased central sympathetic activity. Statins seem to inhibit central sympathetic output. This study assesses the effect of statins on central sympathetic activity in hypertension patients.

Interventions

DRUGatorvastatin 80 mg

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Inclusion criteria

* (Known) hypertension * stable drug therapy for at least 2 months * age 18-70 jaar * BMI 18-35 kg/m2 * Sinusrhythm

Exclusion criteria

* Recent cardiovascular event \<6 mnd * Plasma Creatinin: * female: \>120 mmol/L * male: \>133 mmol/L * use of: * tricyclic antidepressants * alpha-1 -and/or alpha-2 blockers * disease of the autonomic nervous system (Parkinsons disease, Shy- Drager syndrome, etc) * Albuminuria \>300 mg/dag

Design outcomes

Primary

Measure	Time frame
change in central sympathetic activity	—

Secondary

Measure	Time frame
change in cholesterol levels, renin and aldosteron	—

Countries

Netherlands

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026