Cheyne-Stokes Respiration, Heart Failure, Congestive
Conditions
Brief summary
The purpose of the trial is to investigate the cardiovascular response to peripheral chemoreceptor stimulation in Congestive Heart Failure with Cheyne- Stokes Respiration
Interventions
PROCEDUREExperimental lung function test
Administration of several CO2 gas mixtures
Sponsors
ResMed
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Moderate to severe heart failure (NYHA Class II or above) on optimal medical therapy * LVEF less than or equal to 45% * Stable condition as defined as no hospital admission or changes to medical therapy within two weeks prior to enrolment
Exclusion criteria
* Patients taking known respiratory stimulants or depressants * Clinically significant asthma requiring therapy * Significant parenchymal lung disease * Primary pulmonary hypertension * Myocardial infarction within three months prior to enrolment * Patients with cardiac resynchronisation devices and permanent pacemakers * Anaemic (haemoglobin \< 12g/dL)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular parameters such as continuous blood pressure and heart rate. | During administration of the intervention |
Countries
Australia
Outcome results
None listed