What is the Best Preparation for Embryo Transfer in Cryo Cycles: a Natural Cycle or Light Hormonal Stimulation?

Natural Cycle Versus Stimulation With Human Menopausal Gonadotropin in Cycles With Cryopreserved Embryos

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00492934

Enrollment

300

Registered

2007-06-27

Start date

2004-01-31

Completion date

2014-10-31

Last updated

2014-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

subfertility, endometrium thickness, implantation rate, embryo cryopreservation, embryo transfer

Brief summary

The study investigates if, among women with a regular cycle (between 25 and 45 days), the endometrium is better prepared for the transfer of an embryo that was cryopreserved and if the subsequent embryo implantation rate is higher when the cycle is started with daily, small-dose hormonal injections than in cycles without these daily injections.

Interventions

DRUGhuman menopausal gonadotrophins

Daily subcutaneous injections, dose 37.5 IU or 75 IU, start on day 2 of the menstrual cycle until ovulation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

21 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Signed informed consent. * Women with a regular cycle (between 21 and 35 days). * Embryos with 50% intact blastomeres after thawing. * Embryo and endometrium are synchronized.

Exclusion criteria

* Embryo storage time not longer than 5 years.

Design outcomes

Primary

Measure	Time frame
implantation rate per embryo	15 days after the embryo transfer

Secondary

Measure	Time frame
thickness of the endometrium	0-2 days before the human chorionic gonadotropin (hCG) injection

Countries

Belgium

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 15, 2026