Parkinson's Disease
Conditions
Keywords
Parkinson's disease, enteric nervous system
Brief summary
The core of the neuronal lesions in Parkinson's disease (PD) is the progressive degeneration of dopamine neurons in the substantia nigra. A significant loss of dopamine neurons and the presence of Lewy bodies (a pathological hallmark in PD) in enteric neurons have also been reported in that disease. These lesions may explain the frequent gastro-intestinal dysfunction observed in PD patients. Alterations of other neuronal populations within the enteric nervous system (ENS) as well as the mechanisms responsible for these lesions (type of cell death, alteration of neuromediators gene expression) remain to be identified. The aim of the study is to demonstrate that alterations of the human ENS in PD can be evidenced by bowel biopsies and to determine whether they are correlated to the severity of motor disability and to gastrointestinal dysfunction.
Interventions
PROCEDUREBiopsies
Sponsors
Nantes University Hospital
Study design
Intervention model
PARALLEL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Parkinson's disease patients at 3 different stages: * Early PD (before L-DOPA-induced complication); * Patients with L-DOPA-induced complication; * Patients with balance impairment or cognitive decline. * Controls: patient at risk of colic cancer for whom a coloscopy is required.
Countries
France
Outcome results
None listed