Neoplasms
Conditions
Keywords
Carcinomas, Squamous Cel, Adenocarcinoma, Acute Lymphocytic Leukemia
Brief summary
This research involves assessment of cognitive outcome in childhood cancer as well as evaluation of a cognitive rehabilitation program for improving learning and problem solving difficulties in children with cancer.
Detailed description
The purpose of this study is to help determine specific cognitive-behavioral and neurobiologic impairments associated with chemotherapy treatments in children with cancer and to assess the efficacy of a cognitive intervention program for improving cognitive impairments in these children.
Interventions
None listed
Sponsors
Stanford University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
9 Years to 16 Years
Healthy volunteers
Yes
Inclusion criteria
INCLUSION Everyone: * At least 9 years of age and less than 17 years Patients * Diagnosis of brain tumor or acute lymphocytic leukemia (ALL) * Completed all anti-cancer treatment(s) including chemotherapy, radiation and/or surgery Control group * Typical for age EXCLUSION Everyone: * Non-English speaking (translated cognitive testing and MRI assessments unavailable) * MRI contraindication, including but not limited to orthodontia, metal implants, and/or pacemaker * Major sensory deficit disorders, including but not limited to blindness or deafness Patients * Shunt placement * Received bone marrow transplant * History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes) NOT related to cancer * Participation in any concurrent cognitive rehabilitation study Control group * History of neurologic, psychiatric, developmental or major medical condition (eg, diabetes)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Performance on neuropsychological testing and brain activation patterns measured by functional MRI | 8 weeks |
Countries
United States
Outcome results
None listed