Ulcerative Colitis
Conditions
Keywords
Ulcerative colits, lung, Induced sputum, Our aim to evaluate lung involvement in Ulcerative colitis patients by induced sputum
Brief summary
Ulcerative colitis is a systemic disease we assume that extra intestinal involvement as we describein our study( Fireman Z, Osipov A, Kivity S, Kopelman Y, Sternberg A Fireman E: Assessment of pulmonary involvement in Crohn's disease by induced sputum. Am J Gastroenterol 2000;95(30):730-734. )
Detailed description
Twenty Ulcerative colitis patients and 20 control subjects (all nonsmokers) without respiratory symptoms will be tested. The induce sputum by 20' inhalation of 3.5% saline using ultrasonic nebulizer. Samples will studied by differential counts of 200 cells on cytopreps stained by Giemsa. T-lymphocyte subset analyses were done by FACS using three monoclonal antibodies: CD3 = total T cells, CD4 = T helper cells, and CD8 = T suppressor-cytotoxic cells. CD4/CD8 \>2.5 was considered abnormal.
Interventions
PROCEDUREInduced sputum (inhalation of 3.5% saline)
Sponsors
Hillel Yaffe Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* All the ulceratvive colitis patients without lung involvmentage 18-75 years of age
Exclusion criteria
* Pregnant women * Non cooperative patients * Smoker * Lung disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| lung involvment in Ulcerative colitis patients | — |
Outcome results
None listed