Study of Antibiotic Utilization Measures and Control of ESBLs in China

Association of Antibiotic Utilization Measures and Control of Extended-spectrum β-lactamases (ESBLs) in MICU1 and MICU2 at Buddhist Tzu Chi General Hospital.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00488813

Enrollment

300

Registered

2007-06-20

Start date

2004-07-31

Completion date

2005-06-30

Last updated

2009-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU Patient

Keywords

Tzh-Chi ESBL study

Brief summary

A single-center, prospective, comparative, antibiotic intervention study for patients admitted to MICU1 and MICU2

Detailed description

1. To determine the value of using β-lactamases inhibitors in reducing the cases of ESBL producing E. coli or K. pneumoniae colonization and infection after 12 months. 2. To compare the acquisition rates of ESBL producing E. coli or K. pneumoniae at MICU1 and MICU2 after 12 months

Interventions

DRUGThird generation cephalosporins

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All patients admitted or transferred to the ICU/burn units. * Patients of either sex, 18 years of age or older.

Exclusion criteria

* Patient with hypersensitivity to penicillins, cephalosporins, and beta-lactamase inhibitors.

Design outcomes

Primary

Measure	Time frame
For both MICU1 and MICU2 (acquisition), all culture results will be collected and recorded, then analyzed to determine the ESBL acquisition rate and bacterial isolates (E. coli or K. pneumoniae).	—

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026