Chronic Heart Failure
Conditions
Keywords
Chronic heart failure, real time three-dimensional echocardiography, cardiac resynchronization therapy, ventricular asynchrony, systolic dysynchrony index
Brief summary
Patients showing a normal value of SDI (\< or + 8%) will randomly be assigned to CRT in ON or OFFmode at one month after implantation. In any case of emergency, an automated rescue mode is included in the device for the patients in OFF mode.
Detailed description
Patients with a pathological SDI (\> 8%) will as usually be treated by CRT and will serve as control group. The study duration for each patient included in the trial is 6 months. Patients showing a decreased NYHA score by at least one class and an absence of major cardiovascular event during the period will be considered as good responders. The otherswill be considered as no responders. Based on this composite clinical score, the percentage of good responders in each group at 6 months is the primary endpoint of the study. Main secondary endpoints : * Evaluation of the left ventricular function * Exercice capacity * Serious adverse events'frequency * Quality of life (SF36) * Diagnostic and prognostic value of the Brain Natriuretic Peptide(NT pro BNP)evolution.
Interventions
DEVICEDoppler echocardiography
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Both gender * Age\>18 years * Patients in functional class NYHA III or IV * Patient with ejection fraction \<or=150msec or with QRS between 120 and 149 msec but with echocardiographic evidences for cardiac dyssynchrony, such as those retained in the CARE-HF trial, e.g.two from the three following criterions :-Aortic pre-ejection delay\>140msec * Interventricular mechanical delay \>40msec * Delayed activation of the left ventricular postero-lateral wall * Patient under optimal treatment for chronic heart failure for at least one month before inclusion * Written informed consentement
Exclusion criteria
* Patient with atrial fibrillation * Absence of echogenicity * Patient with an indication for pacemaker implantation * Patient suffering from arterial pressure disorders, with systolic pressure greater than 170 or lower than 80 mmHg * Major cardiovascular event within 6 weeks before inclusion * Patient in the exclusion period of any other clinical trial * Patient without social insurance policy * Drug or alcohol addiction * Any psychological disorder * Pregnant women * Patient with a transplanted organ * HIV positive serology at inclusion
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Three parallel arms, randomized, controlled, single blinded, monocentre, clinical trial. | — |
Countries
France
Outcome results
None listed