Pain
Conditions
Keywords
Pain, sensitization, analgesia, Healthy volunteers and pain
Brief summary
Tramadol is a largely used analgesic drug. Its role however on sensitization as occurs for example in neuropathic pain is not very well known. This protocol aims therefore at studying the effect of tramadol in a human pain model with sensitization induced by a cold stimulus, using evoked potentials to elucidate how pain is modified when tramadol is administered.
Detailed description
The study is a comparison of the analgesic of tramadol versus placebo in a pain model using evoked potentials. Evaluation criteria will be the amplitude of the evoked potential obtained defore and after treatment
Interventions
DRUGTramadol
to compare of the analgesic of tramadol versus placebo in a pain model using evoked potentials
Sponsors
University Hospital, Clermont-Ferrand
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men * Between 18 and 40 years old * Written consent given
Exclusion criteria
* Concomitant medication * Tramadol hypersensibility * Excessive consumption of alcohol, tobacco, coffee, tea or toxicomania
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amplitude of the evoked potential elicited by a thermal stimulus on the arm with an induced hyperalgic area | with an induced hyperalgic area |
Countries
France
Outcome results
None listed