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Anger Control Training for Youth With Tourette Syndrome

Anger Control Training for Youth With Tourette Syndrome

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00486551
Enrollment
26
Registered
2007-06-14
Start date
2001-08-31
Completion date
2006-01-31
Last updated
2022-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ADHD, Chronic Tic Disorder, Oppositional Defiant Disorder, Tourette Syndrome

Keywords

Anger control training, Cognitive behavioral therapy, Behavior therapy, Tourette Syndrome, Randomized trial, Anger, Aggression

Brief summary

This is a clinical study of a cognitive-behavioral therapy known as anger control training in adolescents with Tourette Syndrome and explosive, disruptive behavior. ACT is compared to treatment as usual (TAU) in a randomized clinical trial.

Detailed description

This is a randomized controlled study of a cognitive-behavioral, anger control training (ACT) in adolescents with Tourette Syndrome (TS) complicated by disruptive behavior. Disruptive behaviors in TS may take numerous forms including noncompliance, anger outbursts, and physical aggression. Anger outbursts in TS have been described as rage attacks or rage storms due to their high intensity and unpredictability in response to minimal provocation. Whether these behaviors are part of TS, related to comorbid conditions, or due to the burden of chronic illness is not clear. Nevertheless, these disruptive behaviors can result in significant functional impairment and often require clinical attention. The purpose of the ACT intervention is to improve the explosive and noncompliant behavior in adolescents with TS by enhancing affect regulation and social problem-solving skills. The treatment is based on anger control training which has been empirically supported for reducing aggressive behaviors and improving social functioning in aggressive youths. The primary outcome measures include the parent-rated Oppositional Defiant Scale and the Clinicians Global Improvement Score assessed by a clinician blind to treatment assignment.

Interventions

BEHAVIORALAnger control training

Sponsors

National Institute of Mental Health (NIMH)
CollaboratorNIH
Tourette Association of America
CollaboratorOTHER
Yale University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE

Eligibility

Sex/Gender
ALL
Age
11 Years to 16 Years
Healthy volunteers
No

Inclusion criteria

1. Boys and girls, 11 to 16 years of age. 2. Diagnosis of Tourette syndrome (TS) or chronic tic disorder (CTD). 3. Significant level of disruptive behavior

Exclusion criteria

1. Current diagnosis of Severe Major Depression, Bipolar Disorder, Pervasive Developmental Disorder, or Psychotic Disorder. 2. Significant medical condition such as heart disease, hypertension, liver or renal failure, pulmonary disease, seizure disorder that may require more pressing treatment. 3. Initiation or discontinuation of a psychotropic medication treatment within six weeks of enrollment in the study

Design outcomes

Primary

MeasureTime frame
CGI-I assigned by clinician unaware of treatment assignmentthree months
Parent rated disruptive behaviorthree months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 3, 2026