Effect of Meal on Portal and Esophagus Variceal Pressure

Status

Terminated

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00485290

Acronym

VIPE

Enrollment

Registered

2007-06-12

Start date

2007-06-30

Completion date

2008-04-30

Last updated

2008-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis, Esophageal Varices

Keywords

cirrhosis, Portal Hypertension, Esophageal Varices, Meal

Brief summary

The reason why esophagus varices suddenly rupture and start to bleed is unclear. Food intake increase the hepatic blood flow and the portal pressure, but it is yet unknown if there is also an increase in variceal pressure. The aim of this study is to evaluate the efficacy of a meal on variceal pressure with a non invasive endoscopic measurement device, and compare it with portal pressure.

Interventions

BEHAVIORALmeal (food intake)

600 kcal. (16% protein, 49%carbohydrate, 35% fatt)

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Large Esophageal varices

Exclusion criteria

* Treatment with beta-blocking agents * Respiratory diseases that contradict endoscopy * Gastric-retention * Former gastric resection * Resent sclerotherapy or former banding

Design outcomes

Primary

Measure	Time frame
effect of meal on variceal pressure	30 minutes after the meal

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026