Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Conditions
Keywords
primary open angle glaucoma, pseudoexfoliation glaucoma, selective laser trabeculoplasty, intra ocular pressure, anti-inflammatory therapy, prednisolone acetate 1%, ketorolac tromethamine 0.5%
Brief summary
The type of anti-inflammatory medication used post selective laser trabeculoplasty (SLT) may have an impact on the intra-ocular pressure (IOP) lowering effect of SLT. This study will evaluate the IOP lowering effect of SLT following the topical administration of one of the following: prednisolone 1%, ketorolac 0.5% or artificial tears.
Detailed description
Patients who have been chosen to undergo SLT for glaucoma will be randomized to receive one of prednisolone 1%, ketorolac 0.5% or artificial tears four times a day for 5 days following administration of the laser treatment. The IOP will be measured at various time points following SLT: 1 hour, 2 days, 1 week, 1 month, 3 months, 6 months, and 1 year.
Interventions
DRUGprednisolone 1%
eye drop once in each eye treated, 4 times / day for 5 days post-laser
DRUGketorolac 0.5%
eye drop once in each eye treated, 4 times / day for 5 days post-laser
DRUGArtificial Tears (Methyl cellulose drops)
eye drop once in each eye treated, 4 times / day for 5 days post-laser
Sponsors
Pfizer
Glaucoma Research Society of Canada
Queen's University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* primary open angle glaucoma, pseudo exfoliation glaucoma
Exclusion criteria
* previous incisional glaucoma surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraocular pressure lowering effect | 1 hour, 2 days, 1 month, 3 months, 6 months and 1 year |
Secondary
| Measure | Time frame |
|---|---|
| intraocular pressure elevation | 1 hour, 2 days, 1 month |
Countries
Canada
Outcome results
None listed