Polycystic Ovary Syndrome (PCOS) - Effect Of Physical Exercise And Electroacupuncture

Polycystic Ovary Syndrome (PCOS) - The Female Metabolic Syndrome Genes And Processes In The Aetiology And Pathogenesis Of PCOS And Identification Of New Treatment Strategies

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00484705

Acronym

PCOSNTS

Enrollment

Registered

2007-06-11

Start date

2005-10-31

Completion date

2008-10-31

Last updated

2009-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic Ovary Syndrome

Keywords

Androgens, Menstrual pattern, Insulin resistance, Adipocytes, Obesity, Stress, Muscle sympathetic nerve activity, Psychological distress and quality of life

Brief summary

Hypothesis: The overall hypothesis is that women with PCOS, both obese and non-obese, have larger adipocytes, altered metabolism and signs of inflammation in adipose tissue and that these changes are associated with high sympathetic nerve activity, hyperandrogenism hyperinsulinaemia, insulin resistance with progression to type II diabetes and cardiovascular disease (CVD) as well as psychological distress and reduced quality of life. Physical exercise and electro-acupuncture decrease high concentrations of androgens, induce regulare menstrual pattern, inhibits high sympathetic activity and restore the PCOS induced disturbances.

Detailed description

Primary outcome: Changes in androgen concentrations and menstrual pattern Secondary outcome: changes in sympathetic nerve activity, uterus peristalsis, ovarian morphology, adipose tissue related variables, insulin sensitivity, coagulation factors and health related quality of life and symptoms of anxiety and depression.

Interventions

PROCEDUREElectroacupuncture

PROCEDUREPhysical exercise

PROCEDUREUntreated control

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

TREATMENT

Masking

SINGLE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 37 Years

Healthy volunteers

Yes

Inclusion criteria

* To get the diagnosis polycystic ovary syndrome (PCOS), ultrasonography should reveal at least 1 ovary with PCO according to the Rotterdam diagnostic criteria as well as one of the following two symptoms: 1. Anovulation/oligoovulation defined as ≥ 35 days during the last year 2. Clinical signs of hyperandrogenism (hirsutism, acne)

Exclusion criteria

* Cardiovascular disease * Diabetes mellitus * Other endocrine disease (congenital adrenal hyperplasia, androgen producing tumour, Cushing's syndrome) * Estrogen/gestagen treatment during the last 3 months * Breast-feeding the last 6 months * Antiandrogen treatment the last 3 months

Design outcomes

Primary

Measure	Time frame
To measure if physical exercise and electro-acupuncture restores endocrine, neuroendocrine, metabolic and immunological disturbances related to sympathetic nerve activity as well as psychological distress and improve quality of life in women with PCOS.	One year

Countries

Sweden

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 5, 2026