Obesity
Conditions
Keywords
Obesity
Brief summary
The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.
Detailed description
The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.
Interventions
PROCEDUREblood draws
Sponsors
Children's Mercy Hospital Kansas City
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Years to 8 Years
Healthy volunteers
Yes
Inclusion criteria
* Ages 2-8, predominately Caucasian to minimize population stratification
Exclusion criteria
* Chronic diseases (diabetes, cancer, etc) and known syndromes
Countries
United States
Outcome results
None listed