Seasonal Allergic Rhinitis
Conditions
Brief summary
The current study will investigate nasal inflammatory markers obtained by filter paper collection techniques, in subjects with allergic rhinitis, determining the most appropriate time points and handling conditions, prior to running a larger study with subjects with allergic rhinitis.
Interventions
PROCEDUREIntra-nasal allergen challenge with Phleum pratense.
PROCEDURECollection of nasal effluent using filter paper.
PROCEDUREMeasurement of nasal congestion using acoustic rhinometry.
Sponsors
Pfizer
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Male or female subjects with allergic rhinitis, that have a positive skin prick response to Phleum pratense.
Exclusion criteria
* Subjects with a history of asthma. Current smokers, or recent ex-smokers and subjects that have had a respiratory tract infection in the previous 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post allergen challenge nasal inflammatory markers at 1, 5, 15, 30, 45 min, 1, 2, 3, 4, 5, 6, 7, 8 hours post allergen challenge. | — |
Secondary
| Measure | Time frame |
|---|---|
| Post allergen challenge effects on acoustic rhinometry and symptoms at 16, 31, 45 min, 1, 2, 3, 4, 5, 6, 7, 8 hours post allergen challenge. | — |
Countries
United Kingdom
Outcome results
None listed