Phenylephrine Versus Norepinephrine in Septic Shock

Effects of Phenylephrine on Systemic and Regional Hemodynamics in Patients With Septic Shock: a Crossover Pilot Study

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00481442

Enrollment

Registered

2007-06-01

Start date

2007-01-31

Completion date

2007-03-31

Last updated

2007-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Septic Shock

Keywords

Septic shock, Sepsis, Norepinephrine, Phenylephrine

Brief summary

Clinical studies evaluating the clinical use of phenylephrine in septic shock are lacking. The present study was designed to compare the effects of norepinephrine and phenylephrine on systemic and regional hemodynamics in patients with catecholamine-dependent septic shock.

Interventions

DRUGPhenylephrine

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Clical diagnosis of Septic Shock * norepinephrine to maintain mean arterial pressure between 65 and 75 mmHg despite adequate volume resuscitation (pulmonary artery occlusion pressure = 12-18 mmHg and central venous pressure = 8-12 mmHg).

Exclusion criteria

* Age \< 18 years * Pregnancy * Present or suspected acute coronary artery disease * Present or suspected acute mesenteric ischemia.

Design outcomes

Primary

Measure	Time frame
Systemic and regional hemodynamics	24 hours

Secondary

Measure	Time frame
Organ functions, adverse effects	24 hours

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026