Prevalence,Natural History,Prognosis Factor,QualityofLife,Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France

Knee and Hip OsteoArthritis Long Term Assessment. Prevalence, Natural History, Prognosis Factor, Quality of Life, Health Care Consumption and Social Consequences of Symptomatic Knee and Hip Osteoarthritis in France

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00481338

Acronym

KHOALA

Enrollment

878

Registered

2007-06-01

Start date

2007-04-30

Completion date

2019-03-31

Last updated

2015-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip Osteoarthritis, Knee Osteoarthritis

Keywords

Cohort, Quality of life, Health resource use, Disability, Prognosis

Brief summary

The aim of the project is to assemble and to follow on a 10-year period a nationwide representative sample of lower limb OA patients. General objectives: To document the natural history and to identify predictive factors of the evolution and consequences of hip and knee OA in terms of pain, functional disability, structural damage, quality of life, autonomy, medical and health care use and cost of disease.

Interventions

PROCEDUREX-rays

X-rays (hip and knee) every 2 years

BIOLOGICALbiological samples

biological sample (blood and urine) every 2 years

OTHERmedical information about osteoarthritis

several questionnaires about pain and function (WOMAC), physical activity (MAQ), quality of life (generic SF-36 and OA specific OAKHQOL/AMIQUAL), comorbidities (FCI), mental status (MMS), heath status (GHQ 28) and health resource consumption

Study design

Allocation

Intervention model

SINGLE_GROUP

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Inclusion criteria

* male and female aged between 40 and 75 years * symptomatic hip or knee, uni or bilateral OA with clinical diagnosis confirmed by a medical physician and satisfying ACR classification criteria * Representative of prevalent cases in France at the cohort set-up time

Exclusion criteria

* presence of hip or knee joint replacement surgery * comorbidities severe enough to affect quality of life significantly or likely to induce a high health care consumption independently of OA * an history of osteotomy * Patello-femoral osteoarthritis without tibio-femoral osteoarthritis * Other joint diseases of the target joints * adult under legal protection or not able to consent

Design outcomes

Primary

Measure	Time frame
Quality of life, patient reported outcome measures	every year, up to 10 years

Secondary

Measure	Time frame
health care consumption	every year, up to 10 years

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026