Functional Neuroimaging Effects of Cognitive Remediation Training

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00481156

Enrollment

Registered

2007-06-01

Start date

2005-03-01

Completion date

2007-02-28

Last updated

2018-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Brief summary

The purpose of this study is to examine behavioral and functional brain changes occuring as a result of cognitive remediation training in patients with schizophrenia. Extension and specificity of related changes will also be examined.

Interventions

BEHAVIORALCognitive Remediation

BEHAVIORALCognitive Behavioral Social Skills Training

OTHERRetest in Health Controls

Pre/Post test performance and neuroimaging only

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Masking description

Participants were randomized to computer-based cognitive training or active social-skills groups. Healthy controls (n=9) received no treatment.

Intervention model description

Randomized, placebo-controlled, single-blind. An untreated healthy control group was also included to examine simple retest effects.

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* Diagnosis of schizophrenia or schizoaffective disorder * Stable outpatient

Exclusion criteria

* Current drug abuse or dependence * History of neurological damage, disorder, or disease

Design outcomes

Primary

Measure	Time frame	Description
Working Memory performance	Post-test	N-Back Performance
Brain activation	Post-test	Changes in prefrontal cortical functioning

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026