Hepatocellular Carcinoma
Conditions
Keywords
Hepatocellular carcinoma,treatment
Brief summary
Combined the chemoembolization and Radiofrequency ablation for the hepatocellular carcinoma greater than 3 cm,the ablation volume of coagulation necrosis can be significantly increased,which may be enable effective treatment of patients with HCC greater than 3 cm.
Detailed description
To assess whether the effectiveness of a combination of transcatheter arterial chemoembolization(TACE) and radiofrequency ablation(RFA) is superior to TACE and RFA alone in treatment of patients with hepatocellular carcinoma(HCC)greater than 3 cm and to analyze the factors affecting the outcomes. The patients with HCC of 3 or fewer lesions, each 3cm greater in diameter entered this randomized controlled trial. The primary end point was survival, and the secondary end points were tumor response.
Interventions
PROCEDUREchemoembolization ,Radiofrequency ablation
Sponsors
Shandong University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE
Eligibility
Sex/Gender
ALL
Age
45 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Eligibility criteria were: 1. Not indicated for resection, 2. Liver function of Child-Pugh class A or B, 3. 3 or fewer lesion, each 3 cm greater and 7.5 cm less in greatest diameter, 4. No portal vein involvement or extrahepatic metastasis, 5. Lesions located at least 5mm away from the hepatic hilum or gall bladder and the common bile duct, 6. Platelet count≥6.0×103/mm3 and the prothrombin activity≥60%, and 7. No previous HCC treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| overall survival | 5 years |
Secondary
| Measure | Time frame |
|---|---|
| tumor response | 1-6 months |
Outcome results
None listed