fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT00478491

Acronym

ALZ

Enrollment

390

Registered

2007-05-24

Start date

2003-01-31

Completion date

2011-07-31

Last updated

2016-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult Children, Alzheimer's Disease, Dementia, Magnetic Resonance Imaging, Risk

Brief summary

The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* MCI Group: Diagnosis of mild cognitive impairment * AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP) * Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion criteria

* Claustrophobia * Metallic or electronic implants or devices that are not MRI-safe

Countries

United States

Outcome results