Effect of Growth Hormone on Insulin Signaling in Muscle Tissue

The Effect of a Physiological Bolus of Growth Hormone (GH) on Insulin Signaling Pathways in Muscle Tissue From Healthy Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00477997

Enrollment

Registered

2007-05-24

Start date

2007-05-31

Completion date

2008-08-31

Last updated

2009-04-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin Resistance

Keywords

Growth Hormone, Insulin Signaling, GH signaling

Brief summary

The purpose of this study is to examine the effects of a physiological bolus of growth hormone on insulin signaling pathways in muscle tissue in healthy lean men.

Interventions

DEVICEPhysiological Bolus of Growth Hormone

0,5 mg Norditropin

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

MALE

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Male * Healthy * Age between 18 and 30 years * BMI ≤ 26

Exclusion criteria

* Known present disease including diabetes mellitus * BMI \> 26 * Uses any medication * Consumes \> 21 units of alcohol per week

Design outcomes

Primary

Measure	Time frame
PI3-kinase activity i muscle tissue	2 hours

Secondary

Measure	Time frame
Growth Hormone Signaling Proteins in Muscle Tissue and other Insulin Signaling Proteins in Muscle Tissue	2 hours

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 29, 2026