Atypical Depression, Obesity
Conditions
Brief summary
The purpose of this study is to test the effects of chromium picolinate on food intake, food cravings, eating attitudes, and appetite. If chromium picolinate is found to have a beneficial impact on satiety and food intake, then this supplement may be an alternative or adjunctive treatment for overweight people desiring to modify their food intake. The primary hypothesis of this study is that among individuals who report being carbohydrate cravers, chromium picolinate supplementation will reduce food intake during a test lunch meal and produce greater satiety in comparison to a placebo.
Interventions
Test whether Chromium Picolinate supplementation affects food intake at both a test lunch meal and at a test dinner meal presented 4.5 hours later among healthy, overweight and/or obese, adult women who are determined to be carbohydrate creavers.
Sponsors
Nutrition 21, Inc.
Pennington Biomedical Research Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Inclusion criteria are: 1. Healthy female who has not been diagnosed with diabetes, cardiovascular illness, or other chronic diseases, 2. Food craver, determined by self-reported craving for carbohydrates on two out of three validated measures of food cravings, 3. \> 18 years of age and \< 50 years of age, and 4. Body mass index between 25 and 39.9 kg/m2. Participants will be scheduled for testing during the luteal phase of their menstrual cycle to limit the confounding effect of the menstrual cycle on energy intake. We will include women who are taking monophasic oral contraceptives but will exclude other oral contraceptive regimens. Participants with very irregular menstrual cycles will also be excluded because this irregularity will make it very difficult to schedule testing during the luteal phase of the menstrual cycle.
Exclusion criteria
Potential participants will be excluded for the following reasons: 1. Participants who report smoking cigarettes will be excluded because of the effects of nicotine upon taste and appetite, 2. Participants who have a diagnosable eating disorder (i.e., anorexia or bulimia nervosa) will also be excluded since intentional restriction of eating and binge eating/overeating could increase the variability of the data, 3. Participants who report using diet pills will be excluded since diet pills may potentially influence appetite, hunger, and/or satiety, 4. Participants will be excluded if they are taking anti-depressant medications, anti-psychotic medications, or any medications that may potentially influence appetite, hunger, and/or satiety, 5. Participants who are not determined to be carbohydrate cravers will be excluded, 6. Participants will also be excluded if they report any allergies to the foods that will be used in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Food intake at both a test lunch meal and at a test dinner meal presented 4.5 hours later | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Hunger and satiety between the lunch and dinner meal | 8 weeks |
Countries
United States
Outcome results
None listed