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Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Effects of Allopurinol on Diastolic Function in Chronic Heart Failure Patients

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT00477789
Enrollment
Unknown
Registered
2007-05-24
Start date
Unknown
Completion date
Unknown
Last updated
2007-05-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Heart Failure

Keywords

chronic heart failure, diastolic dysfunction, uric acid

Brief summary

In patients with chronic heart failure (CHF)due to dilated cardiomyopathy diastolic dysfunction occurs frequently and is related to a poor outcome. We have previously shown that parameters of diastolic function significantly correlate with uric acid levels, a marker of impaired oxidative metabolism. We aimed to determine whether inhibition of xanthine oxidase with allopurinol might affect diastolic function in patients with CHF.

Interventions

DRUGallopurinol

Sponsors

Universita di Verona
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* chronic heart failure; * left ventricular systolic dysfunction (ejection fraction \<45%) * stable clinical conditions in the previous three months * optimal medical therapy for CHF * normal sinus rhythm * written informed consent * age \>18 years

Exclusion criteria

* renal failure (s-creatinine \>2.5 mg/dl) * already on allopurinol * malignancies * chronic inflammatory diseases

Design outcomes

Primary

MeasureTime frame
diastolic function uric acid levels BNPthree months

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026