Morphine Analgesia in Patients With Acute Appendicitis

Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT00477061

Enrollment

Registered

2007-05-22

Start date

2004-01-31

Completion date

2005-03-31

Last updated

2007-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appendicitis

Keywords

MORPHINE, ANALGESIA, ACUTE APPENDICITS

Brief summary

The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.

Detailed description

Analgesic administration for pain control in patients with acute abdominal pain, regarding acute appendicitis, is controversial. Despite the results previous studies indicating the safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone their use after performing surgical evaluations. Since many patients admitted to ED are unlikely to receive prompt surgical consultation, many of them need pain relief to prevent unnecessary suffering. On the other hand such pain relief must not interfere with the diagnosis and treatment of patients and do not cause any complications. Morphine is a common and effective analgesic which, if shown to have no effect on correct diagnosis of acute abdomen, can be used for this purpose. Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients admitted to ED with the diagnosis of acute appendicitis.

Interventions

DRUGMorphine

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Eligibility

Sex/Gender

ALL

Age

13 Years to 75 Years

Healthy volunteers

Inclusion criteria

* clinical signs of acute appendicitis * planned for appendectomy * supposed to wait for at least 1 hour in the ED before operation

Exclusion criteria

* suspicion to perforated appendicitis * being under the age of 13 * pregnancy (according to history and ß-HCG result) * opium addiction * systolic blood pressure of less than 90 mmHG * known cases of chronic obstructive pulmonary disease (COPD) * known sensitivity to morphine * history of sickle cell disease * self administration of analgesics before enrollment * refusal to participate

Design outcomes

Primary

Measure	Time frame
Pain Intensity	—

Secondary

Measure	Time frame
Diagnostic Accuracy	—

Countries

Iran

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 4, 2026